Carbohydrate Polymers 181 (2018) 801–811 Contents lists available at ScienceDirect Carbohydrate Polymers journal homepage: www.elsevier.com/locate/carbpol Characterization of alginate/chitosan-based nanoparticles and mathematical modeling of their SpBMP-9 release inducing neuronal diﬀerentiation of human SH-SY5Y cells a a a,b,c, Marc-Antoine Lauzon , Bernard Marcos , Nathalie Faucheux Department of Chemical and Biotechnological Engineering, Université de Sherbrooke, 2500 boul. de l’Université, Sherbrooke, Québec, J1K 2R1, Canada Clinical Research Center of Centre Hospitalier Universitaire de Sherbrooke, 12e Avenue N, Sherbrooke, Québec, J1H 5N4, Canada Pharmacology Institute of Sherbrooke, 12e Avenue N, Sherbrooke, Québec, J1H 5N4, Canada ARTICLE I NFO ABSTRACT Keywords: The incidence of brain degenerative disease such as Alzheimer’s disease (AD) will increase as the world popu- Release kinetics lation is ageing. While current AD treatments have only a transient eﬀect, there are many evidences indicating Peptide that some growth factors, such as BMP-9, may be used to treat AD. However, growth factors cannot readily Alzheimer’s disease access the brain because of their size and the presence of the blood brain barrier. We have therefore developed a Diﬀusion small peptide derived from BMP-9, SpBMP-9, which can promote the diﬀerentiation of cholinergic neurons and Neurite outgrowth inactivate GSK3beta, a Tau kinase. Here, we investigated
Carbohydrate Polymers – Elsevier
Published: Feb 1, 2018
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