Article history: Ischemia/reperfusion (I/R) injury of the intestine is the leading cause of organ dysfunction after restora- Received 4 October 2011 tion of blood ﬂow after diverse events, including shock and intestinal transplantation. I/R injury must be Received in revised form overcome for successful small intestinal transplantation. Tight junctions (TJ) are the most apical compo- 19 December 2011 nent of the intercellular junctional complex in epithelial cells; they establish cell polarity and functioning Accepted 12 January 2012 as major determinants of epithelial barrier function. Among the proteins that comprise TJ, the claudin Available online 20 January 2012 family is thought to play a crucial role in homeostasis in multicellular organisms. Therefore, the aim of this study was to examine the changes in function of TJ and behavior of the claudin family during intesti- Keywords: nal I/R. Wistar/ST rats underwent intestinal ischemia by using the spring scale and surgical suture for In vivo intestinal ischemia/reperfusion 1 h, followed by 24 h of reperfusion. We examined the changes in area under the blood concentration Tight junction curve (AUC) after oral administration of FD-4, which is a paracellular marker, and claudin-1, -2, -4, and Claudin family Paracellular permeability -7 mRNA and protein
International Journal of Pharmaceutics – Elsevier
Published: Apr 15, 2012
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