CFD simulation of total and regional fiber deposition in human nasal cavities

CFD simulation of total and regional fiber deposition in human nasal cavities 1 Introduction</h5> The study of fiber deposition in the human respiratory tract is of great importance because of the potential for serious adverse health effects. The nasal airway is the main point of entry for the human respiratory system, and the first line of defense against penetration of particulate pollutants into the lung. The deposition fraction defined as the ratio of the number of deposited particles to the number of particles entering the nostril indicates the fraction of the inhaled fibers that enters the lower respiratory system. Although the use of asbestos fibers has been banned, there are still many old buildings that have asbestos-based insulation. In addition, new fibrous materials such as man-made vitreous fibers (MMVFs) are currently being manufactured for new applications. It has been shown that some particular MMVFs may have adverse carcinogenic effects similar to those of asbestos ( Cavallo et al., 2004 ). Therefore, the potential risk of lung diseases related to fiber inhalation is still a serious health issue. The adverse effects of particulates depend on the region of the airway in which the particles or fibers deposit. Thus, knowledge of regional deposition of fibers in the respiratory tract is of considerable http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Aerosol Science Elsevier

CFD simulation of total and regional fiber deposition in human nasal cavities

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Publisher
Elsevier
Copyright
Copyright © 2013 Elsevier Ltd
ISSN
0021-8502
eISSN
1879-1964
DOI
10.1016/j.jaerosci.2013.12.008
Publisher site
See Article on Publisher Site

Abstract

1 Introduction</h5> The study of fiber deposition in the human respiratory tract is of great importance because of the potential for serious adverse health effects. The nasal airway is the main point of entry for the human respiratory system, and the first line of defense against penetration of particulate pollutants into the lung. The deposition fraction defined as the ratio of the number of deposited particles to the number of particles entering the nostril indicates the fraction of the inhaled fibers that enters the lower respiratory system. Although the use of asbestos fibers has been banned, there are still many old buildings that have asbestos-based insulation. In addition, new fibrous materials such as man-made vitreous fibers (MMVFs) are currently being manufactured for new applications. It has been shown that some particular MMVFs may have adverse carcinogenic effects similar to those of asbestos ( Cavallo et al., 2004 ). Therefore, the potential risk of lung diseases related to fiber inhalation is still a serious health issue. The adverse effects of particulates depend on the region of the airway in which the particles or fibers deposit. Thus, knowledge of regional deposition of fibers in the respiratory tract is of considerable

Journal

Journal of Aerosol ScienceElsevier

Published: Mar 1, 2014

References

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