Cetuximab Combined With Induction Oxaliplatin and Capecitabine, Followed by Neoadjuvant Chemoradiation for Locally Advanced Rectal Cancer: SWOG 0713

Cetuximab Combined With Induction Oxaliplatin and Capecitabine, Followed by Neoadjuvant... Micro-AbstractCetuximab enhances response in KRAS (KRAS proto-oncogene) wild type metastatic colorectal cancer. This trial selected patients with KRAS wild type rectal cancer to assess added benefit from cetuximab in the neoadjuvant setting. Pathologic complete response (pCR) was the surrogate for benefit. Eighty patients were enrolled targeting a pCR rate of 35%, an outcome that was not achieved. This regimen cannot be recommended for general use. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinical Colorectal Cancer Elsevier

Cetuximab Combined With Induction Oxaliplatin and Capecitabine, Followed by Neoadjuvant Chemoradiation for Locally Advanced Rectal Cancer: SWOG 0713

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Publisher
Elsevier
Copyright
Copyright © 2017 Elsevier Inc.
ISSN
1533-0028
eISSN
1936-0674
D.O.I.
10.1016/j.clcc.2017.10.008
Publisher site
See Article on Publisher Site

Abstract

Micro-AbstractCetuximab enhances response in KRAS (KRAS proto-oncogene) wild type metastatic colorectal cancer. This trial selected patients with KRAS wild type rectal cancer to assess added benefit from cetuximab in the neoadjuvant setting. Pathologic complete response (pCR) was the surrogate for benefit. Eighty patients were enrolled targeting a pCR rate of 35%, an outcome that was not achieved. This regimen cannot be recommended for general use.

Journal

Clinical Colorectal CancerElsevier

Published: Mar 1, 2018

References

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