Centrosomal clustering contributes to chromosomal instability and cancer

Centrosomal clustering contributes to chromosomal instability and cancer Available online at www.sciencedirect.com ScienceDirect Centrosomal clustering contributes to chromosomal instability and cancer 1 1 ´ ´ A Milunovic-Jevtic , P Mooney , T Sulerud, J Bisht and JC Gatlin Cells assemble mitotic spindles during each round of division to hallmark of many cancers, affects the chromosome segre- insure accurate segregation of their duplicated genome. In gation machinery in cells and leads to CIN. Specifically, animal cells, stereotypical spindles have two poles, each we introduce the centrosome and provide a brief overview containing one centrosome, from which microtubules are of how centrosome number is controlled in normal cells. nucleated. By contrast, many cancer cells often contain more We then describe a mechanistic link between supernu- than two centrosomes and form transient multipolar spindle merary centrosomes and CIN. Finally, we discuss how structures with more than two poles. In order to divide and cancers maintain the CIN cycle, and potential therapeutic produce viable progeny, the multipolar spindle intermediate strategies designed to force cells to exit the cycle. must be reshaped into a pseudo-bipolar structure via a process called centrosomal clustering. Pseudo-bipolar spindles appear Centrosome structure and function to function normally during mitosis, but they occasionally give Overview of centrosome structure http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Opinion in Biotechnology Elsevier

Centrosomal clustering contributes to chromosomal instability and cancer

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Publisher
Elsevier
Copyright
Copyright © 2016 Elsevier Ltd
ISSN
0958-1669
D.O.I.
10.1016/j.copbio.2016.03.011
Publisher site
See Article on Publisher Site

Abstract

Available online at www.sciencedirect.com ScienceDirect Centrosomal clustering contributes to chromosomal instability and cancer 1 1 ´ ´ A Milunovic-Jevtic , P Mooney , T Sulerud, J Bisht and JC Gatlin Cells assemble mitotic spindles during each round of division to hallmark of many cancers, affects the chromosome segre- insure accurate segregation of their duplicated genome. In gation machinery in cells and leads to CIN. Specifically, animal cells, stereotypical spindles have two poles, each we introduce the centrosome and provide a brief overview containing one centrosome, from which microtubules are of how centrosome number is controlled in normal cells. nucleated. By contrast, many cancer cells often contain more We then describe a mechanistic link between supernu- than two centrosomes and form transient multipolar spindle merary centrosomes and CIN. Finally, we discuss how structures with more than two poles. In order to divide and cancers maintain the CIN cycle, and potential therapeutic produce viable progeny, the multipolar spindle intermediate strategies designed to force cells to exit the cycle. must be reshaped into a pseudo-bipolar structure via a process called centrosomal clustering. Pseudo-bipolar spindles appear Centrosome structure and function to function normally during mitosis, but they occasionally give Overview of centrosome structure

Journal

Current Opinion in BiotechnologyElsevier

Published: Aug 1, 2016

References

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