Available online at www.sciencedirect.com ScienceDirect Centrosomal clustering contributes to chromosomal instability and cancer 1 1 ´ ´ A Milunovic-Jevtic , P Mooney , T Sulerud, J Bisht and JC Gatlin Cells assemble mitotic spindles during each round of division to hallmark of many cancers, affects the chromosome segre- insure accurate segregation of their duplicated genome. In gation machinery in cells and leads to CIN. Speciﬁcally, animal cells, stereotypical spindles have two poles, each we introduce the centrosome and provide a brief overview containing one centrosome, from which microtubules are of how centrosome number is controlled in normal cells. nucleated. By contrast, many cancer cells often contain more We then describe a mechanistic link between supernu- than two centrosomes and form transient multipolar spindle merary centrosomes and CIN. Finally, we discuss how structures with more than two poles. In order to divide and cancers maintain the CIN cycle, and potential therapeutic produce viable progeny, the multipolar spindle intermediate strategies designed to force cells to exit the cycle. must be reshaped into a pseudo-bipolar structure via a process called centrosomal clustering. Pseudo-bipolar spindles appear Centrosome structure and function to function normally during mitosis, but they occasionally give Overview of centrosome structure
Current Opinion in Biotechnology – Elsevier
Published: Aug 1, 2016
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