Anandamide (arachidonylethanolamide) and 2-arachidonoylglycerol mediate many of their actions via either CB 1 or CB 2 cannabinoid receptor subtypes. These agonist-receptor interactions result in activation of G proteins, particularly those of the G i/o family. Signal transduction pathways that are regulated by these G proteins include inhibition of adenylyl cyclase, regulation of ion currents (inhibition of voltage-gated L, N and P/Q Ca 2+ -currents; activation of K + currents); activation of focal adhesion kinase (FAK), mitogen activated protein kinase (MAPK) and induction of immediate early genes; and stimulation of nitric oxide synthase (NOS). Other effects of anandamide and/or 2-arachidonoylglycerol that are not mediated via cannabinoid receptors include inhibition of L-type Ca 2+ channels, stimulation of VR 1 vanilloid receptors, transient changes in intracellular Ca 2+ , and disruption of gap junction function. Cardiovascular regulation by anandamide appears to occur by a variety of receptor-mediated and non-receptor-mediated mechanisms. This review will describe and evaluate each of these signal transduction pathways and mechanisms.
Chemistry and Physics of Lipids – Elsevier
Published: Nov 1, 2000
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