Journal of Critical Care 44 (2018) 124–127 Contents lists available at ScienceDirect Journal of Critical Care journal homepage: www.jccjournal.org Cell free DNA concentration and serum leptin level as predictors of mortality in a sample of septic Egyptian children a, a b b Amaal A. Abdelaal ,Hany A.F.Elghobary ,Sally K. Ibrahiem ,HalaM. Sleem Department of Clinical and Chemical Pathology, Faculty of Medicine, Cairo University, Egypt Department of Pediatrics, Faculty of Medicine, Cairo University, Egypt 1. Introduction There are other cells than adipocytes can produce leptin as an in- ﬂammatory response to infection. Study shown signiﬁcantly greater cel- Sepsis is a systemic inﬂammatory reaction that is caused by bacteria, lular leptin in Human and murine lung tissue after bacterial and viral viruses, fungi or parasites and complicated by organ failure, although pneumonia. In addition there are increased leptin level in humans Bron- the improvements regard diagnosis and treatment of the septic pa- choalveolar lavage (BAL) samples after endotoxin inhalation . tients, sepsis remains the leading cause of death in intensive care units Leptin also has function in growth, immunity and reproduction  (ICUs) [1,2,3]. Many studies revealed that Leptin has a role in cell-mediated immunity Septic patients can diagnose by clinical
Journal of Critical Care – Elsevier
Published: Apr 1, 2018
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