Cell Division: Flipping the Mitotic Switches

Cell Division: Flipping the Mitotic Switches Alternation between DNA replication in the mother cell (S phase) and equal partitioning of the replicated chromosomes to the daughter cells (M phase) during eukaryotic cell division is governed by switches that flip protein kinases on and off. New work reveals that the M-phase promoting kinase is opposed by a phosphatase that also participates in a bistable switching mechanism. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Biology Elsevier

Cell Division: Flipping the Mitotic Switches

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Publisher
Cell Press
Copyright
Copyright © 2016 Elsevier Ltd
ISSN
0960-9822
D.O.I.
10.1016/j.cub.2016.11.007
Publisher site
See Article on Publisher Site

Abstract

Alternation between DNA replication in the mother cell (S phase) and equal partitioning of the replicated chromosomes to the daughter cells (M phase) during eukaryotic cell division is governed by switches that flip protein kinases on and off. New work reveals that the M-phase promoting kinase is opposed by a phosphatase that also participates in a bistable switching mechanism.

Journal

Current BiologyElsevier

Published: Dec 19, 2016

References

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