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Summary The enzyme tissue transglutaminase (tTG) has been recently identified to represent a highly sensitive and specific target of autoantibodies in coeliac disease . To characterize autoantigenic ...
with celiac disease induced a substantial release of interferon-ϒ accompanied by a surge in anti–tissue transglutaminase and antiendomysial autoantibodies , suggesting that those gluten peptides ...
trafficking to the mucosa. In the last year, the first genome wide association study in celiac disease led to the identification of multiple new risk variants. These risk regions implicate genes involved ...
SUMMARY Tissue transglutaminase (tTG) seems to be the target self-antigen for endomysial antibodies in coeliac disease (CD) and to catalyse the critical deamidation of gliadin which strengthens its ...
outside of the diseased colon in UC is well recognized. Many of these EIMs mirror the activity of the colonic disease and are responsive to UC- targeted medical therapies, suggesting that UC and associated ...
- transglutaminase Case reports and series suggest seropositive patients with schizophrenia have symptomatic benefit from gluten-free diets122,124,140 Associated with celiac disease , which shows an epidemiological ...
or pathogenic T cells), (2) indirect (reproduction of the disease in experimental animal models, isolation of autoantibodies or self reactive T cells), and (3) circumstantial ( association with other autoimmune ...
, in coeliac disease , IgA anti-tissue transglutaminase antibodies are extremely useful and specific disease markers [32,33]. Similarly, in primary biliary cirrhosis, IgA autoantibodies against the major ...
syndrome has developed. APS1 is associated with several autoantibodies targeting tissue-specific molecules, and hitherto >15 specific autoantibodies have been described (20–22). Most patients with APS1 also ...
knowledge about the role of inflammation in epileptogenesis, which has gained increasing attention as a potential target for a disease -modifying therapeutic effect (Devinsky et al., 2013; Vezzani et al., 2019 ...
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