Experimental Gerontology 107 (2018) 74–86 Contents lists available at ScienceDirect Experimental Gerontology journal homepage: www.elsevier.com/locate/expgero Causal eﬀects of cardiovascular risk factors on onset of major age-related diseases: A time-to-event Mendelian randomization study Liang He , Irina Culminskaya, Yury Loika, Konstantin G. Arbeev, Olivia Bagley, Matt Duan, Anatoliy I. Yashin, Alexander M. Kulminski Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC 27708, USA ARTICLE I NFO ABSTRACT Keywords: Backgrounds: Elucidating the causal eﬀects of common intermediate risk factors on the onset of age-related Mendelian randomization diseases is indispensable for developing prevention and intervention procedures. Body mass index Methods: We conducted two-stage time-to-event Mendelian randomization meta-analyses combining ﬁve large- Causal eﬀect scale longitudinal cohorts to investigate dynamic causal eﬀects of cardiovascular disease risk factors including Age-related disease body mass index (BMI), systolic blood pressure (SBP), and lipids on the age-at-onset of age-related diseases. We Time-to-event analysis constructed weighted polygenic scores based on genetic markers from previously reported genome-wide asso- ciation studies as instrumental variables to estimate the causal eﬀects. To avoid false positive due to potential pleiotropic eﬀects of the genetic markers, we performed a leave-one-out sensitivity analysis and an MR-Egger sensitivity analysis that we expanded
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera