Catabolic mediators as targets for cancer cachexia

Catabolic mediators as targets for cancer cachexia The cachexia syndrome, characterized by a marked weight loss, anorexia, asthenia and anaemia, is invariably associated with the growth of a tumour and leads to a malnutrition status caused by the induction of anorexia or decreased food intake. In addition, the competition for nutrients between the tumour and the host results in an accelerated catabolism state, which promotes severe metabolic disturbances in the patient. The search for the cachectic factor(s) started a long time ago, and many scientific and economic efforts have been devoted to its discovery, but we are still a long way from a complete answer. The present review aims to evaluate the different molecular mechanisms and catabolic mediators (both humoural and tumoural) that are involved in cancer cachexia and to discuss their potential as targets for future clinical investigations. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Drug Discovery Today Elsevier

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Publisher
Elsevier
Copyright
Copyright © 2003 Elsevier Ltd
ISSN
1359-6446
D.O.I.
10.1016/S1359-6446(03)02826-5
Publisher site
See Article on Publisher Site

Abstract

The cachexia syndrome, characterized by a marked weight loss, anorexia, asthenia and anaemia, is invariably associated with the growth of a tumour and leads to a malnutrition status caused by the induction of anorexia or decreased food intake. In addition, the competition for nutrients between the tumour and the host results in an accelerated catabolism state, which promotes severe metabolic disturbances in the patient. The search for the cachectic factor(s) started a long time ago, and many scientific and economic efforts have been devoted to its discovery, but we are still a long way from a complete answer. The present review aims to evaluate the different molecular mechanisms and catabolic mediators (both humoural and tumoural) that are involved in cancer cachexia and to discuss their potential as targets for future clinical investigations.

Journal

Drug Discovery TodayElsevier

Published: Sep 15, 2003

References

  • Does leptin really influence cancer anorexia?
    Sato, T.
  • Effect of cytokines on hypothalamic neuropeptide Y release in vitro
    King, P.J.
  • Neurochemical mechanisms for cancer anorexia
    Laviano, A.
  • Interleukin-1 receptor antagonist (IL-1ra) is unable to reverse cachexia in rats bearing an ascites hepatoma (Yoshida AH-130)
    Costelli, P.
  • Increased muscle ubiquitin mRNA levels in gastric cancer patients
    Bossola, M.
  • Regulation of skeletal-muscle-protein turnover in cancer-associated cachexia
    Baracos, V.E.
  • Mechanism of depletion of liver glycogen in cancer cachexia
    Hirai, K.
  • Curcumin, a natural product present in turmeric, decreases tumor growth but does not behave as an anticachectic compound in a rat model
    Busquets, S.
  • C/EBP DNA-binding activity is upregulated by a glucocorticoid-dependent mechanism in septic muscle
    Penner, G.

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