Cascade of gene expression induced by Ca 2+ signals in neurons

Cascade of gene expression induced by Ca 2+ signals in neurons To understand the cellular processes involved in learning and memory, the cellular responses of neurons to calcium (Ca 2+ ) signals, which can be evoked via synaptic activity, should be examined. A series of investigations in primary cultures of neurons revealed that the regulation of brain-derived neurotrophic factor (BDNF) mRNA expression is mediated by almost the same Ca 2+ signaling pathways as that of c- fos mRNA expression. Such early co-activation of both genes in response to Ca 2+ signals further suggests that sets of calcium-responsive genes (CaRGs) are concurrently activated by Ca 2+ signals. The products encoded by CaRGs should then evoke a variety of physiological responses in neurons with the expression of another set of genes, the products of which are directly involved in the outcomes of neuronal functions. Thus, a cascade of gene expression can be induced by Ca 2+ signals evoked via synaptic activity. It is of particular interest to identify the CaRGs and investigate the regulational mechanisms of their expression. A cellular approach using primary cultures of neurons would therefore lead to a better understanding of the intracellular processes involved in learning and memory. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Neurochemistry International Elsevier

Cascade of gene expression induced by Ca 2+ signals in neurons

Neurochemistry International, Volume 29 (5) – Nov 1, 1996

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Publisher
Elsevier
Copyright
Copyright © 1996 Elsevier Ltd
ISSN
0197-0186
D.O.I.
10.1016/0197-0186(96)00014-9
Publisher site
See Article on Publisher Site

Abstract

To understand the cellular processes involved in learning and memory, the cellular responses of neurons to calcium (Ca 2+ ) signals, which can be evoked via synaptic activity, should be examined. A series of investigations in primary cultures of neurons revealed that the regulation of brain-derived neurotrophic factor (BDNF) mRNA expression is mediated by almost the same Ca 2+ signaling pathways as that of c- fos mRNA expression. Such early co-activation of both genes in response to Ca 2+ signals further suggests that sets of calcium-responsive genes (CaRGs) are concurrently activated by Ca 2+ signals. The products encoded by CaRGs should then evoke a variety of physiological responses in neurons with the expression of another set of genes, the products of which are directly involved in the outcomes of neuronal functions. Thus, a cascade of gene expression can be induced by Ca 2+ signals evoked via synaptic activity. It is of particular interest to identify the CaRGs and investigate the regulational mechanisms of their expression. A cellular approach using primary cultures of neurons would therefore lead to a better understanding of the intracellular processes involved in learning and memory.

Journal

Neurochemistry InternationalElsevier

Published: Nov 1, 1996

References

  • Rapid rise in transcription factor mRNAs in rat brain after electroshock-induced seizures
    Cole, A.J.; Abu-Shakra, S.; Saffen, D.W.; Baraban, J.M.; Worley, P.F.

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