Cannabinoid receptor antagonism increases female sexual motivation

Cannabinoid receptor antagonism increases female sexual motivation The current experiments examined whether treatment with a CB1 antagonist/inverse agonist (AM251) affects sexual motivation, proceptivity, and receptivity in female rats. In experiment #1, 92 Long–Evans rats were tested for their socio-sexual motivation via a runway methodology. Motivation to approach and maintain close proximity to an empty goalbox, a female, and a male target was assessed following hormonal and drug treatment. Hormone treatments were: oil vehicle, 10 μg estradiol, and 10 μg estradiol + 500 μg progesterone. Drug doses were 0, 2, and 4 mg/kg AM251 (IP, 60 min prior to testing). In experiment #2, 32 female subjects were tested for receptivity and proceptivity in a paced mating chamber. Subjects were given either a high (10 μg estradiol + 500 μg progesterone) or low dose of hormones (2 μg estradiol + 250 μg progesterone), and either vehicle or 2 mg/kg AM251. AM251 significantly increased sexual motivation for a male target in the runway in females primed with both estradiol and progesterone. AM251 also enhanced lordosis (in low hormone females) and increased hop-darts. These findings suggest that endocannabinoids tonically inhibit estrous behaviors. Cannabinoid antagonists could serve as new treatment option for women suffering from abnormally low libido. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Pharmacology Biochemistry and Behavior Elsevier

Cannabinoid receptor antagonism increases female sexual motivation

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Publisher
Elsevier
Copyright
Copyright © 2008 Elsevier Inc.
ISSN
0091-3057
eISSN
1873-5177
D.O.I.
10.1016/j.pbb.2008.10.004
Publisher site
See Article on Publisher Site

Abstract

The current experiments examined whether treatment with a CB1 antagonist/inverse agonist (AM251) affects sexual motivation, proceptivity, and receptivity in female rats. In experiment #1, 92 Long–Evans rats were tested for their socio-sexual motivation via a runway methodology. Motivation to approach and maintain close proximity to an empty goalbox, a female, and a male target was assessed following hormonal and drug treatment. Hormone treatments were: oil vehicle, 10 μg estradiol, and 10 μg estradiol + 500 μg progesterone. Drug doses were 0, 2, and 4 mg/kg AM251 (IP, 60 min prior to testing). In experiment #2, 32 female subjects were tested for receptivity and proceptivity in a paced mating chamber. Subjects were given either a high (10 μg estradiol + 500 μg progesterone) or low dose of hormones (2 μg estradiol + 250 μg progesterone), and either vehicle or 2 mg/kg AM251. AM251 significantly increased sexual motivation for a male target in the runway in females primed with both estradiol and progesterone. AM251 also enhanced lordosis (in low hormone females) and increased hop-darts. These findings suggest that endocannabinoids tonically inhibit estrous behaviors. Cannabinoid antagonists could serve as new treatment option for women suffering from abnormally low libido.

Journal

Pharmacology Biochemistry and BehaviorElsevier

Published: Mar 1, 2009

References

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