Precipitated withdrawal in rats chronically exposed to Δ 9 -tetrahydrocannabinol, the major psychoactive principle of the marijuana plant, was unequivocally demonstrated for the first time using a selective antagonist, SR 141716A ( N -(piperidin-1-yl-5-(4-chlorophenyl)-1(2,4-dichloro-phenyl)-4-methyl-1 H -pyrazole carboxamide · HCl). This demonstration should provide a powerful stimulus for the systematic study of dependency on the psychoactive cannabinoids.
European Journal of Pharmacology – Elsevier
Published: Aug 25, 1995
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