Cannabinoid effects on anxiety-related behaviours and hypothalamic neurotransmitters

Cannabinoid effects on anxiety-related behaviours and hypothalamic neurotransmitters The aim of the present study was to examine the effects of the cannabinoid agonist CP 55,940 and the antagonist SR 141716A, alone and in combination, on rat exploratory and anxiety-like behaviour in the holeboard and elevated plus-maze tests. A further aim was to evaluate the effects of these treatments on hypothalamic neurotransmitters. Animals treated with CP 55,940 doses of 0.125 and 0.1 mg/kg exhibited less exploration and an increase in anxiety-like behaviour accompanied by great motor inhibition. No hypoactivity was seen at 0.075 mg/kg dosage, but anxiety and neophobic responses persisted, indicating independent and specific effects. Motor activity effects induced by CP 55,940 were reversed by pretreatment with SR 141716A (3 mg/kg). Surprisingly, when administered on its own, the antagonist also induced a reduction in exploratory parameters and an increase in anxiety-like responses. These apparently similar effects might be caused by different neural mechanisms. Finally, CP 55,940 increased hypothalamic dopamine and serotonin levels. These increases might be involved in the activation of the hypothalamic–pituitary–adrenal axis described for cannabinoids. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Pharmacology Biochemistry and Behavior Elsevier

Cannabinoid effects on anxiety-related behaviours and hypothalamic neurotransmitters

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Publisher
Elsevier
Copyright
Copyright © 2001 Elsevier Science Inc.
ISSN
0091-3057
eISSN
1873-5177
D.O.I.
10.1016/S0091-3057(01)00578-0
Publisher site
See Article on Publisher Site

Abstract

The aim of the present study was to examine the effects of the cannabinoid agonist CP 55,940 and the antagonist SR 141716A, alone and in combination, on rat exploratory and anxiety-like behaviour in the holeboard and elevated plus-maze tests. A further aim was to evaluate the effects of these treatments on hypothalamic neurotransmitters. Animals treated with CP 55,940 doses of 0.125 and 0.1 mg/kg exhibited less exploration and an increase in anxiety-like behaviour accompanied by great motor inhibition. No hypoactivity was seen at 0.075 mg/kg dosage, but anxiety and neophobic responses persisted, indicating independent and specific effects. Motor activity effects induced by CP 55,940 were reversed by pretreatment with SR 141716A (3 mg/kg). Surprisingly, when administered on its own, the antagonist also induced a reduction in exploratory parameters and an increase in anxiety-like responses. These apparently similar effects might be caused by different neural mechanisms. Finally, CP 55,940 increased hypothalamic dopamine and serotonin levels. These increases might be involved in the activation of the hypothalamic–pituitary–adrenal axis described for cannabinoids.

Journal

Pharmacology Biochemistry and BehaviorElsevier

Published: Sep 1, 2001

References

  • Dopamine receptor-mediated regulation of corticotropin-releasing hormone neurons in the hypothalamic paraventricular nucleus
    Eaton, MJ; Cheung, S; Moore, KE; Lookingland, KJ
  • The excitatory effects of the amygdala on hypothalamo-pituitary–adrenocortical responses are mediated by hypothalamic norepinephrine, serotonin and CRF-41
    Feldman, S; Weidenfeld, J
  • The involvement of serotonin in regulation of pituitary–adrenocortical function
    Fuller, RW
  • Function of cannabinoid receptors in the neuroendocrine regulation of hormone secretion
    Murphy, LL; Muñoz, RM; Adrian, BR; Villanúa, MA
  • Endogenous cannabinoids as an aversive or counter-rewarding system in the rat
    Sañudo-Peña, MC; Tsou, K; Delay, ER; Hohman, AG; Force, M; Walker, JM
  • Improvement of memory in rodents by the selective CB1 cannabinoid receptor antagonist, SR 141716
    Terranova, JP; Storme, JJ; Lafon, N; Pério, A; Rinaldi-Carmona, M; Le Fur, G; Soubrié, P

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