Caloric restriction restores the chronological life span of the goa1 null mutant of Candida albicans in spite of high cell levels of ROS

Caloric restriction restores the chronological life span of the goa1 null mutant of Candida... Highlights ► We show that the GOA1 mutant of Candida albicans dies in high glucose. ► However, caloric restriction (CR) rescues mutant cells. ► During CR, ROS is much higher than control strains but cells survive. ► An up regulation of alternate carbon metabolism genes occurs during CR. ► We describe the relationship of CR and aging in a fungal pathogen. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Fungal Genetics and Biology Elsevier

Caloric restriction restores the chronological life span of the goa1 null mutant of Candida albicans in spite of high cell levels of ROS

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Abstract

Highlights ► We show that the GOA1 mutant of Candida albicans dies in high glucose. ► However, caloric restriction (CR) rescues mutant cells. ► During CR, ROS is much higher than control strains but cells survive. ► An up regulation of alternate carbon metabolism genes occurs during CR. ► We describe the relationship of CR and aging in a fungal pathogen.

Journal

Fungal Genetics and BiologyElsevier

Published: Dec 1, 2012

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