(Ca 2+ ) i regulation by glutamate receptor agonists in cultured chick retina cells

(Ca 2+ ) i regulation by glutamate receptor agonists in cultured chick retina cells The effect of glutamate receptor agonists on the intracellular free calcium concentration ((Ca 2+ ) i ), measured with Indo-1, was studied in populations of cultured chick embryonic retina cells. The agonists of the ionotropic glutamate receptors, N -methyl- d -aspartate (NMDA), kainate, and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) increased the (Ca 2+ ) i through a composite effect, comprising Ca 2+ permeating the receptor-associated channels, and Ca 2+ entering through voltage-gated Ca 2+ channels. Furthermore, the (Ca 2+ i responses to NMDA and AMPA also involved Ca 2+ release from intracellular stores, which could not be mobilized by stimulation of the metabotropic receptor. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Vision Research Elsevier

(Ca 2+ ) i regulation by glutamate receptor agonists in cultured chick retina cells

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Publisher
Elsevier
Copyright
Copyright © 1996 Elsevier Science Ltd. All rights reserved
ISSN
0042-6989
eISSN
1878-5646
D.O.I.
10.1016/0042-6989(95)00208-1
Publisher site
See Article on Publisher Site

Abstract

The effect of glutamate receptor agonists on the intracellular free calcium concentration ((Ca 2+ ) i ), measured with Indo-1, was studied in populations of cultured chick embryonic retina cells. The agonists of the ionotropic glutamate receptors, N -methyl- d -aspartate (NMDA), kainate, and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) increased the (Ca 2+ ) i through a composite effect, comprising Ca 2+ permeating the receptor-associated channels, and Ca 2+ entering through voltage-gated Ca 2+ channels. Furthermore, the (Ca 2+ i responses to NMDA and AMPA also involved Ca 2+ release from intracellular stores, which could not be mobilized by stimulation of the metabotropic receptor.

Journal

Vision ResearchElsevier

Published: Apr 1, 1996

References

  • Two types of glutamate receptors differentially excite amacrine cells in the tiger salamander retina
    Dixon, D.; Copenhagen, D.
  • Dantrolene prevents glutamate cytotoxicity and Ca 2+ release from intracellular stores in cultured cerebral cortical neurons
    Frandsen, A.; Schousboe, A.
  • Cloned glutamate receptors
    Hollmann, M.; Heinemann, S.
  • Permeation of calcium through excitatory amino acid receptor channels in cultured rat hippocampal neurones
    Iino, M.; Ozawa, S.; Tsuzuki, K.
  • Permeation and block of N -methyl- d -aspartic acid receptor channels by divalent cations in mouse cultured central neurones
    Mayer, M.L.; Westbrook, L.
  • Brief calcium transients evoked by glutamate receptor agonists in rat dorsal horn neurons: Fast kinetics and mechanisms
    Reichling, D.B.; MacDermott, A.B.
  • Sustained and transient calcium currents in horizontal cells of the white bass retina
    Sullivan, J.M.; Lasater, E.M.
  • Inhibitory modulation by sodium ions of the N -methyl- d -aspartate recognition site in brain synaptic membranes
    Yoneda, Y.; Ogita, K.

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