Bridging the structural gap of glycoproteomics with ion mobility spectrometry

Bridging the structural gap of glycoproteomics with ion mobility spectrometry •Differentiation of closely related glycans and glycoconjugates is feasible with high resolution IMS.•Examining different adducts, charge states, or different drift gasses adds orthogonality for resolving glycans by IMS.•CCS databases may enable detailed glycan structural analysis from IM-MS data alone.•Post-fragmentation IM-MS can elucidate glycan structures at a site-specific level. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Opinion in Chemical Biology Elsevier

Bridging the structural gap of glycoproteomics with ion mobility spectrometry

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Publisher
Elsevier
Copyright
Copyright © 2017 Elsevier Ltd
ISSN
1367-5931
D.O.I.
10.1016/j.cbpa.2017.11.012
Publisher site
See Article on Publisher Site

Abstract

•Differentiation of closely related glycans and glycoconjugates is feasible with high resolution IMS.•Examining different adducts, charge states, or different drift gasses adds orthogonality for resolving glycans by IMS.•CCS databases may enable detailed glycan structural analysis from IM-MS data alone.•Post-fragmentation IM-MS can elucidate glycan structures at a site-specific level.

Journal

Current Opinion in Chemical BiologyElsevier

Published: Feb 1, 2018

References

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