Brain segmentation and forebrain development in amniotes

Brain segmentation and forebrain development in amniotes This essay contains a general introduction to the segmental paradigm postulated for interpreting morphologically cellular and molecular data on the developing forebrain of vertebrates. The introduction examines the nature of the problem, indicating the role of topological analysis in conjunction with analysis of various developmental cell processes in the developing brain. Another section explains how morphological analysis in essence depends on assumptions (paradigms), which should be reasonable and well founded in other research, but must remain tentative until time reveals their necessary status as facts for evolving theories (or leads to their substitution by alternative assumptions). The chosen paradigm affects many aspects of the analysis, including the sectioning planes one wants to use and the meaning of what one sees in brain sections. Dorsoventral patterning is presented as the fundament for defining what is longitudinal, whereas less well-understood anteroposterior patterning results from transversal regionalization. The concept of neural segmentation is covered, first historically, and then step by step, explaining the prosomeric model in basic detail, stopping at the diencephalon, the extratelencephalic secondary prosencephalon, and the telencephalon. A new pallial model for telencephalic development and evolution is presented as well, updating the proposed homologies between the sauropsidian and mammalian telencephalon. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Brain Research Bulletin Elsevier

Brain segmentation and forebrain development in amniotes

Brain Research Bulletin, Volume 55 (6) – Aug 1, 2001

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Publisher
Elsevier
Copyright
Copyright © 2001 Elsevier Science Inc.
ISSN
0361-9230
eISSN
1873-2747
DOI
10.1016/S0361-9230(01)00588-3
Publisher site
See Article on Publisher Site

Abstract

This essay contains a general introduction to the segmental paradigm postulated for interpreting morphologically cellular and molecular data on the developing forebrain of vertebrates. The introduction examines the nature of the problem, indicating the role of topological analysis in conjunction with analysis of various developmental cell processes in the developing brain. Another section explains how morphological analysis in essence depends on assumptions (paradigms), which should be reasonable and well founded in other research, but must remain tentative until time reveals their necessary status as facts for evolving theories (or leads to their substitution by alternative assumptions). The chosen paradigm affects many aspects of the analysis, including the sectioning planes one wants to use and the meaning of what one sees in brain sections. Dorsoventral patterning is presented as the fundament for defining what is longitudinal, whereas less well-understood anteroposterior patterning results from transversal regionalization. The concept of neural segmentation is covered, first historically, and then step by step, explaining the prosomeric model in basic detail, stopping at the diencephalon, the extratelencephalic secondary prosencephalon, and the telencephalon. A new pallial model for telencephalic development and evolution is presented as well, updating the proposed homologies between the sauropsidian and mammalian telencephalon.

Journal

Brain Research BulletinElsevier

Published: Aug 1, 2001

References

  • Are pioneer axons guided by regulatory gene expression domains in the zebrafish forebrain? High-resolution analysis of the patterning of the zebrafish brain during axon tract formation
    Hjörth, J.T.; Key, B.
  • Fate mapping of the mouse prosencephalic neural plate
    Inoue, T.; Nakamura, S.; Osumi, N.
  • The specification of dorsal cell fates in the vertebrate central nervous system
    Lee, K.J.; Jessell, T.M.
  • Morphological fate of rhombomeres in quail/chick chimeras
    Marı́n, F.; Puelles, L.
  • Regionalization of the prosencephalic neural plate
    Rubenstein, J.L.R.; Shimamura, K.; Martı́nez, S.; Puelles, L.
  • Development of the nervous system
    Sanes, D.H.; Reh, T.A.; Harris, W.A.

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