Brain androgen and progesterone metabolizing enzymes: biosynthesis, distribution and function

Brain androgen and progesterone metabolizing enzymes: biosynthesis, distribution and function This review summarizes the biosynthesis, cell type-distribution and function of brain aromatase cytochrome P450 (P450aro) and 5α-reductase enzymes. This overview covers the impact of the steroid products of the P450aro and 5α-reductase enzymes in establishing sexually dimorphic brain structures, specifically the sexually dimorphic nucleus of the preoptic area (SDN) and the anteroventral periventricular nucleus (AVPV). Additionally, since metabolites of the P450aro and 5α-reductase enzymes are known to regulate the calcium-binding protein, calbindin (CALB), CALB is reviewed in relationship to its potential role in determining sexually dimorphic brain structures. Finally, recent reports indicate that phytoestrogens inhibit P450aro and 5α-reductase activities in peripheral tissue sites, therefore, the effects of phytoestrogens on brain P450aro and 5α-reductase are briefly considered and the impact of consuming a high vs. a low phytoestrogen diet on visual spatial memory in male and female rats is presented. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Brain Research Reviews Elsevier

Brain androgen and progesterone metabolizing enzymes: biosynthesis, distribution and function

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Publisher
Elsevier
Copyright
Copyright © 2001 Elsevier Science B.V.
ISSN
0165-0173
DOI
10.1016/S0165-0173(01)00111-4
Publisher site
See Article on Publisher Site

Abstract

This review summarizes the biosynthesis, cell type-distribution and function of brain aromatase cytochrome P450 (P450aro) and 5α-reductase enzymes. This overview covers the impact of the steroid products of the P450aro and 5α-reductase enzymes in establishing sexually dimorphic brain structures, specifically the sexually dimorphic nucleus of the preoptic area (SDN) and the anteroventral periventricular nucleus (AVPV). Additionally, since metabolites of the P450aro and 5α-reductase enzymes are known to regulate the calcium-binding protein, calbindin (CALB), CALB is reviewed in relationship to its potential role in determining sexually dimorphic brain structures. Finally, recent reports indicate that phytoestrogens inhibit P450aro and 5α-reductase activities in peripheral tissue sites, therefore, the effects of phytoestrogens on brain P450aro and 5α-reductase are briefly considered and the impact of consuming a high vs. a low phytoestrogen diet on visual spatial memory in male and female rats is presented.

Journal

Brain Research ReviewsElsevier

Published: Nov 1, 2001

References

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