Bone matrix microdamage and vascular changes characterize bone marrow lesions in the subchondral bone of knee osteoarthritis

Bone matrix microdamage and vascular changes characterize bone marrow lesions in the subchondral... IntroductionBone marrow lesions (BMLs) in the subchondral bone in osteoarthritis (OA) are suggested to be multifactorial, although the pathogenic mechanisms are unknown. Bone metabolism and cardiovascular risk factors associate with BML in epidemiologic studies. However, there are no studies at the tissue level investigating the relationship between these processes and BML. The aim of this study was to investigate the relationship between BMLs in the tibial plateau (TP) of knee OA and bone matrix microdamage, osteocyte density and vascular changes. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Bone Elsevier

Bone matrix microdamage and vascular changes characterize bone marrow lesions in the subchondral bone of knee osteoarthritis

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Publisher
Elsevier
Copyright
Copyright © 2018 Elsevier Ltd
ISSN
8756-3282
D.O.I.
10.1016/j.bone.2018.01.012
Publisher site
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Abstract

IntroductionBone marrow lesions (BMLs) in the subchondral bone in osteoarthritis (OA) are suggested to be multifactorial, although the pathogenic mechanisms are unknown. Bone metabolism and cardiovascular risk factors associate with BML in epidemiologic studies. However, there are no studies at the tissue level investigating the relationship between these processes and BML. The aim of this study was to investigate the relationship between BMLs in the tibial plateau (TP) of knee OA and bone matrix microdamage, osteocyte density and vascular changes.

Journal

BoneElsevier

Published: Mar 1, 2018

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