Blimp-1 prolongs allograft survival without regimen via influencing T cell development in favor of regulatory T cells while suppressing Th1

Blimp-1 prolongs allograft survival without regimen via influencing T cell development in favor... •Blimp-1 is expressed in multiple cell lineages and in particular, T cells.•It is the first study for allograft survival in Blimp-1 T-cell transgenic mice.•Blimp-1 T-cells modulate skin allograft survival without immunosuppression.•T-bet reduction and FoxP3 increment occur in Blimp-1 T-cells.•Blimp-1 creates a favorable condition via Th1 suppression and Treg amplification. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Molecular Immunology Elsevier

Blimp-1 prolongs allograft survival without regimen via influencing T cell development in favor of regulatory T cells while suppressing Th1

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Publisher
Elsevier
Copyright
Copyright © 2018 Elsevier Ltd
ISSN
0161-5890
D.O.I.
10.1016/j.molimm.2018.04.004
Publisher site
See Article on Publisher Site

Abstract

•Blimp-1 is expressed in multiple cell lineages and in particular, T cells.•It is the first study for allograft survival in Blimp-1 T-cell transgenic mice.•Blimp-1 T-cells modulate skin allograft survival without immunosuppression.•T-bet reduction and FoxP3 increment occur in Blimp-1 T-cells.•Blimp-1 creates a favorable condition via Th1 suppression and Treg amplification.

Journal

Molecular ImmunologyElsevier

Published: Jul 1, 2018

References

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