Bisphenol A exposure is associated with oxidative stress and inflammation in postmenopausal women

Bisphenol A exposure is associated with oxidative stress and inflammation in postmenopausal women Bisphenol A (BPA) is widely used in the production of polycarbonate plastics and epoxy resins. There is increasing health concerns regarding low-level exposure to BPA among the general population. The aim of this study was to determine the association between BPA exposure with oxidative stress and inflammation in adult populations. A cross-sectional study was conducted. This study included 485 adults (259 men, 92 premenopausal women, and 134 postmenopausal women) living in general communities within large cities. Urinary concentrations of BPA, malondialdehyde (MDA), and 8-hydroxydeoxyguanosine (8-OHdG), white blood cell (WBC) count, and C-reactive protein (CRP) were measured. Multivariate analyses were applied to determine the associations of BPA exposure with oxidative stress and inflammation. The geometric means of urinary BPA for men, premenopausal women, and postmenopausal women were 0.53, 0.61, and 0.58 μg/g cr, respectively. The urinary BPA concentrations were positively associated with MDA, 8-OHdG, and CRP levels in the postmenopausal women; however, such associations did not exist in men and premenopausal women. The findings of this study suggest that BPA exposure would promote oxidative stress and inflammation, in which postmenopausal women are likely to be more susceptible to BPA-induced health effects. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Environmental Research Elsevier

Bisphenol A exposure is associated with oxidative stress and inflammation in postmenopausal women

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Publisher
Elsevier
Copyright
Copyright © 2009 Elsevier Inc.
ISSN
0013-9351
eISSN
1096-0953
DOI
10.1016/j.envres.2009.04.014
Publisher site
See Article on Publisher Site

Abstract

Bisphenol A (BPA) is widely used in the production of polycarbonate plastics and epoxy resins. There is increasing health concerns regarding low-level exposure to BPA among the general population. The aim of this study was to determine the association between BPA exposure with oxidative stress and inflammation in adult populations. A cross-sectional study was conducted. This study included 485 adults (259 men, 92 premenopausal women, and 134 postmenopausal women) living in general communities within large cities. Urinary concentrations of BPA, malondialdehyde (MDA), and 8-hydroxydeoxyguanosine (8-OHdG), white blood cell (WBC) count, and C-reactive protein (CRP) were measured. Multivariate analyses were applied to determine the associations of BPA exposure with oxidative stress and inflammation. The geometric means of urinary BPA for men, premenopausal women, and postmenopausal women were 0.53, 0.61, and 0.58 μg/g cr, respectively. The urinary BPA concentrations were positively associated with MDA, 8-OHdG, and CRP levels in the postmenopausal women; however, such associations did not exist in men and premenopausal women. The findings of this study suggest that BPA exposure would promote oxidative stress and inflammation, in which postmenopausal women are likely to be more susceptible to BPA-induced health effects.

Journal

Environmental ResearchElsevier

Published: Aug 1, 2009

References

  • Elimination of cotinine from body fluids: implications for noninvasive measurement of tobacco smoke exposure
    Jarvis, M.J.; Russell, M.A.; Benowitz, N.L.; Feyerabend, C.
  • Plasma malondialdehyde as biomarker for oxidative stress: reference interval and effects of life-style factors
    Nielsen, F.; Mikkelsen, B.B.; Nielsen, J.B.; Andersen, H.R.; Grandjean, P.
  • Measurement of bisphenol A in human urine using liquid chromatography with multi-channel coulometric electrochemical detection
    Ouchi, K.; Watanabe, S.
  • Dietary exposure to xenoestrogens in New Zealand
    Thomson, B.M.; Cressey, P.J.; Shaw, I.C.

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