Bioprocessing Strategies for Pluripotent Stem Cells Based on Waddington’s Epigenetic Landscape

Bioprocessing Strategies for Pluripotent Stem Cells Based on Waddington’s Epigenetic Landscape As increasing numbers of cell-based therapies advance through clinical trials towards approval for use in humans, the need for robust and well-characterized cell culturing strategies is becoming increasingly apparent. We discuss here novel stem cell bioprocessing strategies based on the concept of using Waddington’s epigenetic landscape to represent the process of cellular decision-making during development. Specifically, we focus on the manner in which cell behavior triggers cell signaling pathways related to the initial cell fate decision. We also consider how various biochemical engineering strategies can be used to develop these bioprocesses to further enhance their utility in research and therapy. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Trends in Biotechnology Elsevier

Bioprocessing Strategies for Pluripotent Stem Cells Based on Waddington’s Epigenetic Landscape

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Publisher
Elsevier Current Trends
Copyright
Copyright © 2017 Elsevier Ltd
ISSN
0167-7799
D.O.I.
10.1016/j.tibtech.2017.10.006
Publisher site
See Article on Publisher Site

Abstract

As increasing numbers of cell-based therapies advance through clinical trials towards approval for use in humans, the need for robust and well-characterized cell culturing strategies is becoming increasingly apparent. We discuss here novel stem cell bioprocessing strategies based on the concept of using Waddington’s epigenetic landscape to represent the process of cellular decision-making during development. Specifically, we focus on the manner in which cell behavior triggers cell signaling pathways related to the initial cell fate decision. We also consider how various biochemical engineering strategies can be used to develop these bioprocesses to further enhance their utility in research and therapy.

Journal

Trends in BiotechnologyElsevier

Published: Jan 1, 2018

References

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