Available online at www.sciencedirect.com ScienceDirect Biomimetic strategies for engineering composite tissues 1 1,2 1 Nancy Lee , Jennifer Robinson and Helen Lu The formation of multiple tissue types and their integration into the ﬁeld of tissue regeneration moves to join these single- composite tissue units presents a frontier challenge in tissue systems into composite tissue units and integrate regenerative engineering. Tissue–tissue synchrony is crucial in these composite tissue grafts to reestablish biological providing structural support for internal organs and enabling function in vivo. daily activities. This review highlights the state-of-the-art in composite tissue scaffold design, and explores how Synchronized tissue units are especially important in the biomimicry can be strategically applied to avoid over- musculoskeletal system, whereby physiological motion is engineering the scaffold. Given the complexity of biological orchestrated through concerted actions of bone in con- tissues, determining the most relevant parameters for junction with a variety of soft tissues. The tissue–tissue recapitulating native structure–function relationships through junctions through which they integrate are characterized strategic biomimicry will reduce the burden for clinical by multiple matrix regions that exhibit spatial changes in translation. It is anticipated that these exciting efforts in cell phenotype, matrix composition, and organization that composite tissue
Current Opinion in Biotechnology – Elsevier
Published: Aug 1, 2016
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