Available online at www.sciencedirect.com ScienceDirect Biomaterials approaches to modeling macrophage– extracellular matrix interactions in the tumor microenvironment 1,2 1,2,3 Nora L Springer and Claudia Fischbach Tumors are characterized by aberrant extracellular matrix cancer independently [5,6], and their reciprocal actions (ECM) remodeling and chronic inﬂammation. While advances in propagate tissue dysfunction in other conditions such as biomaterials and tissue engineering strategies have led to obesity . Nevertheless, the functional connections important new insights regarding the role of ECM composition, between ﬁbrosis and macrophage functions and the structure, and mechanical properties in cancer in general, the resulting effect on tumorigenesis remain unclear functional link between these parameters and macrophage (Figure 1). phenotype is poorly understood. Nevertheless, increasing experimental evidence suggests that macrophage behavior is Tumor-associated and obesity-associated ﬁbrosis can be similarly controlled by physicochemical properties of the ECM attributed to increased presence of activated ﬁbroblasts, and consequential changes in mechanosignaling. Here, we will which mediate changes in extracellular matrix (ECM) summarize the current knowledge of macrophage biology and deposition. Activated ﬁbroblasts are typically referred to ECM-mediated differences in mechanotransduction and as cancer-associated ﬁbroblasts (CAF) or myoﬁbroblasts discuss future opportunities of biomaterials and tissue and are characterized by excessive deposition of ﬁbrillar
Current Opinion in Biotechnology – Elsevier
Published: Aug 1, 2016
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