Bioactivity and structure–activity relationship of cinnamic acid derivatives and its heteroaromatic ring analogues as potential high-efficient acaricides against Psoroptes cuniculi

Bioactivity and structure–activity relationship of cinnamic acid derivatives and its... Bioorganic & Medicinal Chemistry Letters 28 (2018) 1149–1153 Contents lists available at ScienceDirect Bioorganic & Medicinal Chemistry Letters journal homepage: www.elsevier.com/locate/bmcl Bioactivity and structure–activity relationship of cinnamic acid derivatives and its heteroaromatic ring analogues as potential high-efficient acaricides against Psoroptes cuniculi a a ⇑ ⇑ Dong-Dong Chen , Bing-Yu Zhang , Xiu-Xiu Liu, Xing-Qiang Li, Xin-Juan Yang , Le Zhou College of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi 712100, China article i nfo abstract Article history: A series of cinnamic acid derivatives and its heteroaromatic ring analogues were synthesized and Received 16 March 2017 evaluated for acaricidal activity in vitro against Psoroptes cuniculi, a mange mite. Among them, eight Revised 14 August 2017 compounds showed the higher activity with median lethal concentrations (LC ) of 0.36–1.07 mM Accepted 19 August 2017 (60.4–192.1 mg/mL) and great potential for the development of novel acaricidal agent. Compound 40 Available online 24 August 2017 showed both the lowest LC value of 0.36 mM (60.4 mg/mL) and the smallest median lethal time (LT ) of 2.6 h at 4.5 mM, comparable with ivermectin [LC = 0.28 mM (247.4 mg/mL), LT = 8.9 h], an 50 50 50 Keywords: acaricidal drug standard. SAR http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Bioorganic & Medicinal Chemistry Letters Elsevier

Bioactivity and structure–activity relationship of cinnamic acid derivatives and its heteroaromatic ring analogues as potential high-efficient acaricides against Psoroptes cuniculi

Loading next page...
1
 
/lp/elsevier/bioactivity-and-structure-activity-relationship-of-cinnamic-acid-ehEFIFVgXI
Publisher
Elsevier
Copyright
Copyright © 2017 Elsevier Ltd
ISSN
0960-894x
D.O.I.
10.1016/j.bmcl.2017.08.051
Publisher site
See Article on Publisher Site

Abstract

Bioorganic & Medicinal Chemistry Letters 28 (2018) 1149–1153 Contents lists available at ScienceDirect Bioorganic & Medicinal Chemistry Letters journal homepage: www.elsevier.com/locate/bmcl Bioactivity and structure–activity relationship of cinnamic acid derivatives and its heteroaromatic ring analogues as potential high-efficient acaricides against Psoroptes cuniculi a a ⇑ ⇑ Dong-Dong Chen , Bing-Yu Zhang , Xiu-Xiu Liu, Xing-Qiang Li, Xin-Juan Yang , Le Zhou College of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi 712100, China article i nfo abstract Article history: A series of cinnamic acid derivatives and its heteroaromatic ring analogues were synthesized and Received 16 March 2017 evaluated for acaricidal activity in vitro against Psoroptes cuniculi, a mange mite. Among them, eight Revised 14 August 2017 compounds showed the higher activity with median lethal concentrations (LC ) of 0.36–1.07 mM Accepted 19 August 2017 (60.4–192.1 mg/mL) and great potential for the development of novel acaricidal agent. Compound 40 Available online 24 August 2017 showed both the lowest LC value of 0.36 mM (60.4 mg/mL) and the smallest median lethal time (LT ) of 2.6 h at 4.5 mM, comparable with ivermectin [LC = 0.28 mM (247.4 mg/mL), LT = 8.9 h], an 50 50 50 Keywords: acaricidal drug standard. SAR

Journal

Bioorganic & Medicinal Chemistry LettersElsevier

Published: Apr 1, 2018

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off