Access the full text.
Sign up today, get unlimited access with DeepDyve Pro!
-2 (Ace2), or angiotensin 1 - 7 (Ang 1 - 7 ) receptor (MasR) gene promoters. Genetic deletion of Nrf2 or pharmacological inhibition of Nrf2 in Akita mice attenuated hypertension, renal injury ...
Abstract Background. Pharmacological interruption of the angiotensin II type- 1 receptor (AT1) signalling during nephrogenesis in rats induces irreversible abnormalities in kidney morphology ...
expression in normal and cyclosporine-treated rat kidney . Kidney Int 2001; 60: 847–857 Google Scholar 7 Hannedouche TP, Natov S, Boitard C, Lacour B, Grunfeld JP. Angiotensin converting enzyme inhibition ...
of angiotensin (Ang)-( 1 - 7 ) or the hydrolysis of Ang A in the heart.[6] Ang A was identified by in 2007,[ 7 ] and its level was higher in the chronic kidney disease.[8] Ala plays a similar role to that of Ang-( 1 - 7 ...
fibrogenesis [ 7 , 8] and epithelial -to-mesenchymal transition (EMT) [9]. Erlotinib (Tarceva) and gefitinib (Iressa) are small molecule tyrosine kinase inhibitors (TKIs) that compete with the binding of adenosine ...
homeostasis through the main effector peptide angiotensin II (Ang II). Ang II exerts these physiologic actions in many target organs including the kidneys , adrenal glands, heart, blood vessels and brain. 1 ,,,–5 ...
an inhibitory regulator by competing with activated Smad 1 for binding to Smad 4. Smad 7 inhibits the TGF-β/Smad pathway by binding to the TGF-β type 1 receptors and preventing phosphorylation of Smads 2 and 3 ...
, such as kidney injury molecule 1 (KIM- 1 ), neutrophil gelatinase-associated lipocalin and N-acetyl-β-d-glucosaminidase (NAG) [ 7 , 8]. Regression of microalbuminuria in Type 1 diabetes mellitus was found ...
Physiol 1990; 258: F259–F265 Google Scholar 7 Ray PE, Aguilera G, Kopp JB, Horikoshi S, Klotman PE. Angiotensin II receptor mediated proliferation of cultured human fetal mesangial cells. Kidney Int 1991 ...
high glucose per se, advanced glycation end-products and their carbonyl intermediates, angiotensin II, and ultrafiltered growth factors activate a number of signaling pathways including nuclear factor ...
Access the full text.
Sign up today, get unlimited access with DeepDyve Pro!