Acta Biomaterialia 71 (2018) 420–431 Contents lists available at ScienceDirect Acta Biomaterialia journal homepage: www.elsevier.com/locate/actabiomat Full length article Beyond the protein corona – lipids matter for biological response of nanocarriers a,b,1 a,1 a a a,b Julius Müller , Domenik Prozeller , Artur Ghazaryan , Maria Kokkinopoulou , Volker Mailänder , a,⇑ a,⇑ Svenja Morsbach , Katharina Landfester Max Planck Institute for Polymer Research, Ackermannweg 10, 55128 Mainz, Germany Dermatology Clinic, University Medical Center Mainz, Langenbeckstraße 1, 55131 Mainz, Germany ar ti c l e i nf o ab stra ct Article history: The interaction of nanocarriers with blood plasma components inﬂuences the biological response, and Received 13 November 2017 therefore, it needs to be controlled. Whereas protein adsorption to nanocarriers has been investigated Received in revised form 25 January 2018 to a large extent, the role of lipid interaction for drug delivery and its biological effect is not yet clear. Accepted 28 February 2018 However, lipids represent an important constituent of blood plasma and are usually bound in the form Available online 7 March 2018 of lipoproteins. Because already for many nanocarrier systems an enrichment of apolipoproteins in their protein corona was reported, we examine the interaction of lipoproteins
Acta Biomaterialia – Elsevier
Published: Apr 15, 2018
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