Beyond the protein corona – lipids matter for biological response of nanocarriers

Beyond the protein corona – lipids matter for biological response of nanocarriers Acta Biomaterialia 71 (2018) 420–431 Contents lists available at ScienceDirect Acta Biomaterialia journal homepage: www.elsevier.com/locate/actabiomat Full length article Beyond the protein corona – lipids matter for biological response of nanocarriers a,b,1 a,1 a a a,b Julius Müller , Domenik Prozeller , Artur Ghazaryan , Maria Kokkinopoulou , Volker Mailänder , a,⇑ a,⇑ Svenja Morsbach , Katharina Landfester Max Planck Institute for Polymer Research, Ackermannweg 10, 55128 Mainz, Germany Dermatology Clinic, University Medical Center Mainz, Langenbeckstraße 1, 55131 Mainz, Germany ar ti c l e i nf o ab stra ct Article history: The interaction of nanocarriers with blood plasma components influences the biological response, and Received 13 November 2017 therefore, it needs to be controlled. Whereas protein adsorption to nanocarriers has been investigated Received in revised form 25 January 2018 to a large extent, the role of lipid interaction for drug delivery and its biological effect is not yet clear. Accepted 28 February 2018 However, lipids represent an important constituent of blood plasma and are usually bound in the form Available online 7 March 2018 of lipoproteins. Because already for many nanocarrier systems an enrichment of apolipoproteins in their protein corona was reported, we examine the interaction of lipoproteins http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Acta Biomaterialia Elsevier

Beyond the protein corona – lipids matter for biological response of nanocarriers

Loading next page...
 
/lp/elsevier/beyond-the-protein-corona-lipids-matter-for-biological-response-of-25APq3yyLr
Publisher
Elsevier
Copyright
Copyright © 2018 Acta Materialia Inc.
ISSN
1742-7061
eISSN
1878-7568
D.O.I.
10.1016/j.actbio.2018.02.036
Publisher site
See Article on Publisher Site

Abstract

Acta Biomaterialia 71 (2018) 420–431 Contents lists available at ScienceDirect Acta Biomaterialia journal homepage: www.elsevier.com/locate/actabiomat Full length article Beyond the protein corona – lipids matter for biological response of nanocarriers a,b,1 a,1 a a a,b Julius Müller , Domenik Prozeller , Artur Ghazaryan , Maria Kokkinopoulou , Volker Mailänder , a,⇑ a,⇑ Svenja Morsbach , Katharina Landfester Max Planck Institute for Polymer Research, Ackermannweg 10, 55128 Mainz, Germany Dermatology Clinic, University Medical Center Mainz, Langenbeckstraße 1, 55131 Mainz, Germany ar ti c l e i nf o ab stra ct Article history: The interaction of nanocarriers with blood plasma components influences the biological response, and Received 13 November 2017 therefore, it needs to be controlled. Whereas protein adsorption to nanocarriers has been investigated Received in revised form 25 January 2018 to a large extent, the role of lipid interaction for drug delivery and its biological effect is not yet clear. Accepted 28 February 2018 However, lipids represent an important constituent of blood plasma and are usually bound in the form Available online 7 March 2018 of lipoproteins. Because already for many nanocarrier systems an enrichment of apolipoproteins in their protein corona was reported, we examine the interaction of lipoproteins

Journal

Acta BiomaterialiaElsevier

Published: Apr 15, 2018

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off