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- Publisher
- Elsevier
- Copyright
- Copyright © 2016 Elsevier Inc.
- ISSN
- 0197-4580
- D.O.I.
- 10.1016/j.neurobiolaging.2016.01.004
- Publisher site
- See Article on Publisher Site
Abstract
Beta-hydroxy-beta-methylbutyrate (HMB), a supplement commonly used to maintain muscle in elderly and clinical populations, has been unexplored in the aging brain. In both healthy aging humans and rat models, there are cognitive deficits associated with age-related dendritic shrinkage within the prefrontal cortex. The present study explores the effects of relatively short- and long-term (7 and 31 weeks) oral HMB supplementation starting at 12 months of age in male and female rats on the dendritic tree of layer 5 pyramidal neurons in the medial prefrontal cortex. Since female rats continue to secrete ovarian hormones after reaching reproductive senescence, middle-aged female rats were ovariectomized to model humans. As expected, there were fewer spines and a retraction of dendritic material in the apical and basilar trees in old age controls of both sexes compared with their middle-aged counterparts. However, these losses did not occur in the HMB-treated rats in either dendrites or the total number of dendritic spines. Thus, HMB forestalled the effects of aging on the dendritic tree of this population of neurons.
Journal
Neurobiology of Aging – Elsevier
Published: Apr 1, 2016
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References
-
Circulating insulin-like growth factor I and cognitive function: neuromodulation throughout the lifespanAleman, A.; Torres-Alemán, I.
-
Correlation of cognitive performance and morphological changes in neocortical pyramidal neurons in agingAllard, S.; Scardochio, T.; Cuello, A.C.; Ribeiro-da-Silva, A.
-
Morphological and molecular changes in aging rat prelimbic prefrontal cortical synapsesBloss, E.B.; Puri, R.; Yuk, F.; Punsoni, M.; Hara, Y.; Janssen, W.G.; McEwen, B.S.; Morrison, J.H.
-
Nutrient biomarker patterns, cognitive function, and MRI measures of brain agingBowman, G.L.; Silbert, L.C.; Howieson, D.; Dodge, H.H.; Traber, M.G.; Frei, B.; Kaye, J.A.; Shannon, J.; Quinn, J.F.
-
Neural plasticity in the ageing brainBurke, S.N.; Barnes, C.A.
-
Insulin-like growth factor 1 is essential for normal dendritic growthCheng, C.M.; Mervis, R.F.; Niu, S.L.; Salem, N.; Witters, L.A.; Tseng, V.; Reinhardt, R.; Bondy, C.A.
-
Effects of long-term treatment with estrogen and medroxyprogesterone acetate on synapse number in the medial prefrontal cortex of aged female ratsChisholm, N.C.; Juraska, J.M.
-
The effects of long-term treatment with estradiol and medroxyprogesterone acetate on tyrosine hydroxylase fibers and neuron number in the medial prefrontal cortex of aged female ratsChisholm, N.C.; Packard, A.R.; Koss, W.A.; Juraska, J.M.
-
Emerging roles of astrocytes in neural circuit developmentClarke, L.E.; Barres, B.A.
-
Quantitative cerebral anatomy of the aging human brain: a cross-sectional study using magnetic resonance imagingCoffey, C.E.; Wilkinson, W.E.; Parashos, I.A.; Soady, S.A.R.; Sullivan, R.J.; Patterson, L.J.; Figiel, G.S.; Webb, M.C.; Spritzer, C.E.; Djang, W.T.
-
Age-related changes in prefrontal cortex of Macaca mulatta: quantitative analysis of dendritic branching patternsCupp, C.J.; Uemura, E.
-
Spatial memory formation and memory-enhancing effect of glucose involves activation of the tuberous sclerosis complex-mammalian target of rapamycin pathwayDash, P.K.; Orsi, S.A.; Moore, A.N.
-
Layer-specific dendritic regression of pyramidal cells with ageing in the human prefrontal cortexde Brabander, J.M.; Kramers, R.J.; Uylings, H.B.
-
Age-related dendritic and spine changes in corticocortically projecting neurons in macaque monkeysDuan, H.; Wearne, S.L.; Rocher, A.B.; Macedo, A.; Morrison, J.H.; Hof, P.R.
-
Signaling pathways initiated by β-hydroxy-β-methylbutyrate to attenuate the depression of protein synthesis in skeletal muscle in response to cachectic stimuliEley, H.L.; Russell, S.T.; Baxter, J.H.; Mukerji, P.; Tisdale, M.J.
-
The neurobiology of memory changes in normal agingErickson, C.A.; Barnes, C.A.
-
The ovariectomized, mature rat model of postmenopausal osteoporosis: an assessment of the bone sparing effects of curcuminFrench, D.L.; Muir, J.M.; Webber, C.E.
-
The use of animal models to study the effects of aging on cognitionGallagher, M.; Rapp, P.R.
-
Neuroprotection by estradiolGarcia-Segura, L.M.; Azcoitia, I.; DonCarlos, L.L.
-
Ageing, exercise and food restriction: effects on body compositionGarthwaite, S.M.; Cheng, H.; Bryan, J.E.; Craig, B.W.; Holloszy, J.O.
-
Chronic supplementation of beta-hydroxy-beta methylbutyrate (HMβ) increases the activity of the GH/IGF-I axis and induces hyperinsulinemia in ratsGerlinger-Romero, F.; Guimarães-Ferreira, L.; Giannocco, G.; Nunes, M.T.
-
Locally Synthesized Growth Hormone Enhances Spine Density in the Amygdala. Program No. 81.13. 2014 Neuroscience Meeting PlannerGisabella, B.; Yao, J.; Goosens, K.A.
-
Mechanisms of translational control in dendritesGlanzer, J.
-
Analysis of thick brain sections by obverse-reverse computer microscopy: application of a new, high clarity Golgi-Nissl stainGlaser, E.M.; Van der Loos, H.
-
Glucose and age-related changes in memoryGold, P.E.
-
Multiple mechanisms mediate cholesterol-induced synaptogenesis in a CNS neuronGoritz, C.; Mauch, D.H.; Pfrieger, F.W.
-
Effects of a Bioactive Nutrient on Memory and Cognitive Flexibility in a Rodent Model of Aging. Program No. 359.02. 2014 Neuroscience Meeting PlannerGulley, J.M.; Hankosky, E.R.; Ruvola, L.A.; Sherrill, L.K.; Keeley, C.J.; Patel, R.A.; Ghane, M.A.; Hammerslag, L.R.; Kim, T.; Kougias, D.G.; Juraska, J.M.
-
mTOR signaling: at the crossroads of plasticity, memory and diseaseHoeffer, C.; Klann, E.
-
Patterns of sex steroid and gonadotropin secretion in aging female ratsHuang, H.H.; Steger, R.W.; Bruni, J.F.; Meites, J.
-
Life-span dendritic and spine changes in areas 10 and 18 of human cortex: a quantitative Golgi studyJacobs, B.; Driscoll, L.; Schall, M.
-
The Effects of Daily Supplementation with a Bioactive Nutrient on Age-related Declines in Working Memory in Male and Female Rats. Program No. 359.03. 2014 Neuroscience Meeting PlannerJuraska, J.M.; Sherrill, L.K.; Ruvola, L.A.; Kofsky, N.M.; Keeley, C.J.; Ghane, M.A.; Hankosky, E.R.; Hammerslag, L.R.; Kim, T.; Kougias, D.G.; Gulley, J.M.
-
The electrotonic structure of pyramidal neurons contributing to prefrontal cortical circuits in macaque monkeys is significantly altered in agingKabaso, D.; Coskren, P.J.; Henry, B.I.; Hof, P.R.; Wearne, S.L.
-
Dendritic remodeling in the adolescent medial prefrontal cortex and the basolateral amygdala of male and female ratsKoss, W.A.; Belden, C.E.; Hristov, A.D.; Juraska, J.M.
-
The Effects of HMB on Water Maze Performance in Middle-aged and Aged Male and Female Rats. Program No. 579.09. 2013 Neuroscience Meeting PlannerKougias, D.G.; Koss, W.A.; Sherrill, L.K.; Hammerslag, L.R.; Hankosky, E.R.; Gulley, J.M.; Juraska, J.M.
-
Activity-dependent Phosphorylation of P70 Ribosomal S6 Kinase (P70S6K) by Cdk5 Is Required for Dendritic Spine Maturation. Program No. 39.21. 2013 Neuroscience Meeting PlannerLai, K.O.; Fei, E.; Ip, N.Y.
-
OP054 regulation of neuronal survival factors by β-hydroxy-β-methylbutyrate (HMB): future therapeutic implicationsLopez-Pedrosa, J.M.; Girón, M.D.; Vilchez, D.; Manzano, M.; Rueda, R.; Salto, R.
-
Methods of dendritic spine detection: from Golgi to high-resolution optical imagingMancuso, J.J.; Chen, Y.; Li, X.; Xue, Z.; Wong, S.T.
-
Aging and sex influence the anatomy of the rat anterior cingulate cortexMarkham, J.A.; Juraska, J.M.
-
CNS synaptogenesis promoted by glia-derived cholesterolMauch, D.H.; Nagler, K.; Schumacher, S.; Goritz, C.; Muller, E.-C.; Otto, A.; Pfrieger, F.W.
-
Effects of training on weight, food intake, and body composition in aging ratsMazzeo, R.S.; Horvath, S.M.
-
Nutritional role of the leucine metabolite β-hydroxy β-methylbutyrate (HMB)Nissen, S.L.; Abumrad, N.N.
-
Permeation of growth hormone across the blood-brain barrierPan, W.; Yu, Y.; Cain, C.M.; Nyberg, F.; Couraud, P.O.; Kastin, A.J.
-
Aging of the human ovary and testisPerheentupa, A.; Huhtaniemi, I.
-
HMB use and its relationship to exercise-induced muscle damage and performance during exerciseRouthier, D.D.; Stacy, J.J.
-
β-Hydroxy- β-Methylbutyrate (HMB) promotes neurite outgrowth in neuro2a cellsSalto, R.; Vilchez, J.D.; Girón, M.D.; Cabrera, E.; Campos, N.; Manzano, M.; Rueda, R.; López-Pedrosa, J.M.
-
Quantitative determination of β-hydroxymethylbutyrate and leucine in culture media and microdialysates from ratbrain by UHPLC-tandem mass spectrometrySantos-Fandila, A.; Zafra-Gómez, A.; Barranco, A.; Navalón, A.; Rueda, R.; Ramírez, M.
-
The measurable parameters of the cerebral cortex and their significance in its organizationSholl, D.A.
-
Alterations in insulin-like growth factor-1 gene and protein expression and type 1 insulin-like growth factor receptors in the brains of ageing ratsSonntag, W.E.; Lynch, C.D.; Bennett, S.; Khan, S.; Thornton, P.L.; Cooney, P.T.; Ingram, R.L.; McShane, T.; Brunso-Bechtold, J.K.
-
Effects of aging on food intake and body composition in ratsThomas, M.A.; Rice, H.B.; Weinstock, D.; Corwin, R.L.
-
Chronic [D-Ala2]-growth hormone-releasing hormone administration attenuates age-related deficits in spatial memoryThornton, P.L.; Ingram, R.L.; Sonntag, W.E.
-
Regional frontal cortical volumes decrease differentially in aging: an MRI study to compare volumetric approaches and voxel-based morphometryTisserand, D.J.; Pruessner, J.C.; Sanz Arigita, E.J.; van Boxtel, M.P.; Evans, A.C.; Jolles, J.; Uylings, H.B.
-
Age-related changes in prefrontal cortex of Macaca mulatta: synaptic densityUemura, E.
-
Mammalian target of rapamycin complex 1 (mTORC1) and 2 (mTORC2) control the dendritic arbor morphology of hippocampal neuronsUrbanska, M.; Gozdz, A.; Swiech, L.J.; Jaworski, J.
-
beta-hydroxy-beta-methylbutyrate (HMB) kinetics and the influence of glucose ingestion in humansVukovich, M.D.; Slater, G.; Macchi, M.B.; Turner, M.J.; Fallon, K.; Boston, T.; Rathmacher, J.
-
Beta-hydroxy-beta-methyl-butyrate blunts negative age-related changes in body composition, functionality and myofiber dimensions in ratsWilson, J.M.; Grant, S.C.; Lee, S.; Masad, I.S.; Park, Y.; Henning, P.C.; Stout, J.R.; Loenneke, J.P.; Arjmandi, B.H.; Panton, L.B.; Kim, J.
-
Effect of ovariectomy on plasma LH, FSH, estradiol, and progesterone and medial basal hypothalamic LHRH concentrations in old and young ratsWise, P.M.; Ratner, A.
-
mTOR and autophagy in normal brain aging and caloric restriction ameliorating age-related cognition deficitsYang, F.; Chu, X.; Yin, M.; Liu, X.; Yuan, H.; Niu, Y.; Fu, L.
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