Behavioral sensitization to heroin by cannabinoid pretreatment in the rat

Behavioral sensitization to heroin by cannabinoid pretreatment in the rat The behavioral consequences of acute heroin challenge (0.5 mg/kg, s.c.) were measured in rats previously submitted to repeated administration of increasing doses of the synthetic cannabinoid receptor agonist, R (+)-(2,3-dihydro-5-methyl-3-((morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazinyl)-(1-naphthalenyl) methanone mesylate (WIN55212.2) (first day 2 mg/kg, second day 4 mg/kg, third day 8 mg/kg) or vehicle. Heroin administration to rats pretreated with vehicle produced catalepsy. The same dose of heroin in WIN55212.2-pretreated rats was followed by a marked increase of locomotor activity with stereotyped and non-stereotyped behaviors. These effects were blocked by the opioid receptor antagonist, naloxone. These findings indicate that pretreatment with WIN55212.2 produces cross-sensitization to heroin in the rat. These changes might reflect long-lasting changes of receptor population or transcriptional mechanisms in the mesolimbic system. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Pharmacology Elsevier

Behavioral sensitization to heroin by cannabinoid pretreatment in the rat

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Publisher
Elsevier
Copyright
Copyright © 2001 Elsevier Ltd
ISSN
0014-2999
D.O.I.
10.1016/S0014-2999(01)01056-1
Publisher site
See Article on Publisher Site

Abstract

The behavioral consequences of acute heroin challenge (0.5 mg/kg, s.c.) were measured in rats previously submitted to repeated administration of increasing doses of the synthetic cannabinoid receptor agonist, R (+)-(2,3-dihydro-5-methyl-3-((morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazinyl)-(1-naphthalenyl) methanone mesylate (WIN55212.2) (first day 2 mg/kg, second day 4 mg/kg, third day 8 mg/kg) or vehicle. Heroin administration to rats pretreated with vehicle produced catalepsy. The same dose of heroin in WIN55212.2-pretreated rats was followed by a marked increase of locomotor activity with stereotyped and non-stereotyped behaviors. These effects were blocked by the opioid receptor antagonist, naloxone. These findings indicate that pretreatment with WIN55212.2 produces cross-sensitization to heroin in the rat. These changes might reflect long-lasting changes of receptor population or transcriptional mechanisms in the mesolimbic system.

Journal

European Journal of PharmacologyElsevier

Published: Jun 15, 2001

References

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