Axonal regeneration of retinal ganglion cells: effect of trophic factors

Axonal regeneration of retinal ganglion cells: effect of trophic factors A variety of neurotrophic factors can influence the cell functions of the developing, mature and injured retinal ganglion cells. The discovery that retinal ganglion cell loss can be alleviated by neurotrophic factors has generated a great deal of interest in the therapeutic potential of these molecules. Recently, evidence has provided valuable information on the receptors that mediate these events and the intracellular signaling cascades after the binding of these ligands. Signaling by neurotrophic factors does not seem to restrict to retrograde messenger from the target but also includes local interactions with neighbouring cells along the axonal pathways, anterograde signaling from the afferents and autocrine signaling. More insight into the mechanisms of action of neurotrophic factors and the signal transduction pathway leading to the protection and regeneration of retinal ganglion cells may allow the design of new therapeutic strategies. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Progress in Retinal and Eye Research Elsevier

Axonal regeneration of retinal ganglion cells: effect of trophic factors

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Publisher
Elsevier
Copyright
Copyright © 2000 Elsevier Science Ltd
ISSN
1350-9462
eISSN
1873-1635
DOI
10.1016/S1350-9462(00)00009-4
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Abstract

A variety of neurotrophic factors can influence the cell functions of the developing, mature and injured retinal ganglion cells. The discovery that retinal ganglion cell loss can be alleviated by neurotrophic factors has generated a great deal of interest in the therapeutic potential of these molecules. Recently, evidence has provided valuable information on the receptors that mediate these events and the intracellular signaling cascades after the binding of these ligands. Signaling by neurotrophic factors does not seem to restrict to retrograde messenger from the target but also includes local interactions with neighbouring cells along the axonal pathways, anterograde signaling from the afferents and autocrine signaling. More insight into the mechanisms of action of neurotrophic factors and the signal transduction pathway leading to the protection and regeneration of retinal ganglion cells may allow the design of new therapeutic strategies.

Journal

Progress in Retinal and Eye Research – Elsevier

Published: Sep 1, 2000

References

  • Detection of brain-derived neurotrophic factor-like activity in fibroblasts and Schwann cells: inhibition by antibodies to NGF
    Acheson, A; Barker, P.A; Alderson, R.F; Miller, F.D; Murphy, R.A
  • Cholinergic neuronotrophic factors: intraocular distribution of soluble trophic activity for ciliary neurons
    Adler, R; Landa, K.B; Manthrope, M; Varon, S
  • Regulation of neurotrophin receptors during the maturation of the mammalian visual system
    Allendoerfer, D.M; Cabelli, R.J; Escandon, E; Kaplan, D.R; Nikolics, K; Shatz, C.J
  • GDNF family neurotrophic factor signaling: four masters, one servant?
    Airaksinen, M.S; Titievsky, A; Saarma, M
    Bookmark
  • GDNF prevents degeneration and promotes the phenotype of brain noradrenergic neurons in vivo
    Arenas, E; Trupp, M; Akerud, P; Ibanez, C.F
  • Retinal ganglion cell survival and neurite regeneration requirements: the change from Müller cell dependence to superior colliculi dependence during development
    Armson, P.F; Bennett, M.R; Raju, T.R
  • Adult rat retinal glia in vitro : effects of in vivo crush-activation on glia proliferation and permissiveness for regenerating retinal ganglion cell axons
    Bähr, M
  • Ability of adult rat ganglion cells to regrow axons in vitro can be influenced by fibroblast growth factor and gangliosides
    Bähr, M; Vanselow, J; Thanos, S
  • Insulin-like growth factor I in cultured rat astrocytes: expression of the gene, and tyrosine kinase
    Ballotti, R; Nielsen, F.C; Pringle, N; Kowalski, A; Richardson, W.D; Van Obberghen, E; Gammeltoft, S
  • The Trk family of neurotrophin receptors
    Barbacid, M
  • Expression of IGF-I and insulin receptor genes in the rat central nervous system: a developmental, regional, and cellular analysis
    Baron-van Evercooren, A; Olichon-Berthe, C; Kowalski, A; Visciano, G; Van Obberghen, E
    Bookmark
  • Development of the neuromuscular synapse. Invited lecture
    Bennett, M.R
  • Axotomy results in delayed death and apoptosis of retinal ganglion cells in adult rats
    Berkelaar, M; Clarke, D.B; Wang, Y.C; Bray, G.M; Aguayo, A.J
  • Unequivocal regeneration of rat optic nerve axons into sciatic nerve isografts
    Berry, M; Ree, L; Sievers, J
  • Optic axons regenerate into sciatic nerve isografts only in the presence of Schwann cells
    Berry, M; Rees, L; Hall, S; Yiu, P; Sievers, J
  • Peripheral nerve explants grafted into the vitreous body of the eye promote the regeneration of retinal ganglion cell axons severed in the optic nerve
    Berry, M; Carlile, J; Hunter, A
  • Neuritogenesis of retinal ganglion cells is differentially promoted by target extract
    Bosco, A; Carri, N.G; Linden, R
  • Fibroblast growth factor receptor function is required for the orderly projection of ganglion cell axons in the developing mammalian retina
    Brittis, P.A; Silver, J; Walsh, F.S; Doherty, P
    Bookmark
  • GDNF is an age-specific survival factor for sensory and autonomic neurons
    Buj-Bello, A; Buchman, V.L; Horton, A; Rosenthal, A; Davies, A.M
  • Prior exposure to neurotrophins blocks inhibition of axonal regeneration by MAG and myelin via a cAMP-dependent mechanism
    Cai, D; Shen, Y; De Bellard, M; Tang, S; Filbin, M.T
  • Spontaneous axonal regeneration after optic nerve injury in adult rat
    Campbell, G; Holt, J.K.L; Shotton, H.R; Anderson, P.N; Bavetta, S; Lieberman, A.R
  • Effect of NGF on the survival of rat retinal ganglion cells following optic nerve section
    Carmignoto, G; Maffei, L; Candeo, P; Canella, R; Comelli, C
  • Expression of NGF receptor and NGF receptor mRNA in the developing and adult rat brain
    Carmignoto, G; Comelli, M.C; Candeo, P; Cavicchioli, L; Yan, Q; Merighi, A; Maffei, L
  • Differential regulation of p21ras activation in neurons by nerve growth factor and brain-derived neurotrophic factor
    Carter, B.D; Zirrgiebel, U; Barde, Y.A
  • Brain-derived neurotrophic factor/neurotrophin-4 receptor TrkB is localized on ganglion cells and dopaminergic amacrine cells in the vertebrate retina
    Cellerino, A; Kohler, K
  • A study of the survival of retinal ganglion cells following a damage of the retinocollicular projection at the brachium of superior colliculus in adult hamsters
    Chau, W.K; So, K.F; Tay, D
  • Bcl-2 promotes regeneration of severed axons in mammalian CNS
    Chen, D.F; Schneider, G.E; Martinou, J.C; Tonegawa, S
  • Rate of regrowth of damaged retinal ganglion cell axons regenerating in a peripheral nerve graft in adult hamsters
    Cho, E.Y; So, K.F
  • Characterization of the sprouting response of axon-like processes from retinal ganglion cells after axotomy in adult hamsters: a model using intravitreal implantation of a peripheral nerve
    Cho, E.Y; So, K.F
  • Intravitreal transplantation of a peripheral nerve enhances c-Jun expression in a subpopulation of axotomized retinal ganglion cells in hamsters
    Cho, K.S; Shen, L; So, K.F; Chung, S.K
  • Ciliary neurotrophic factor promotes the regrowth capacity but not the survival of intraorbitally axotomized retinal ganglion cells in adult hamsters
    Cho, K.S; Chan, P.M; So, K.F; Yip, H.K; Chung, S.K
  • Synergistic effect of optic and peripheral nerve grafts on sprouting of axon-like processes of axotomized retinal ganglion cells in adult hamsters
    Cho, K.S; Xiao, Y.M; So, K.F; Diao, Y.C; Chung, S.K
    Bookmark
  • Localization of basic fibroblast growth factor binding sites in the chick embryonic neural retina
    Cirillo, A; Arruti, C; Courtois, Y; Jeanny, J.C
  • Prolonged administration of NT-4/5 fails to rescue most axotomized retinal ganglion cells in adult rats
    Clarke, D.B; Bray, G.M; Aguayo, A.J
    Bookmark
  • Neurotrophin-4/5 (NT-4/5) increases adult rat retinal ganglion cell survival and neurite outgrowth in vitro
    Cohen, A; Bray, G.M; Aguayo, A.J
  • BDNF in the development of the visual system of Xenopus
    Cohen-Cory, S; Fraser, S.E
    Bookmark
  • Effects of brain-derived neurotrophic factor on optic axon branching and remodelling in vivo
    Cohen-Cory, S; Fraser, S.E
  • Effects of exogenous nerve growth factor upon sympathetic sprouting into the hippocampal formation
    Conner, J.M; Varon, S
    Bookmark
  • Selection and control in neurogenesis
    Cowan, W.M
  • NT-4/5 reduces naturally occurring retinal ganglion cell death in neonatal rats
    Cui, Q; Harvey, A.R
  • At least two mechanisms are involved in the death of retinal ganglion cells following target ablation in neonatal rats
    Cui, Q; Harvey, A.R
  • CNTF, not other trophic factors, promotes axonal regeneration of axotomized retinal ganglion cells in adult hamsters
    Cui, Q; Lu, Q; So, K.F; Yip, H.K
  • Naturally occurring neuron death in the ganglion cell layer of the neonatal rat: morphology and evidence for regional correspondence with neuron death in superior colliculus
    Cunningham, T.J; Mohler, I.M; Giordano, D.L
  • Spatio-temporal distribution of acidic and basic FGF indicates a role for FGF in rat lens morphogenesis
    de Iongh, R; McAvoy, J.W
    Bookmark
  • Role of neurotrophins in the control of neural development: neurotrophin-3 promotes both neuron differentiation and survival of cultured chick retinal ganglion cells
    de la Rosa, E.J; Arribas, A; Frade, J.M; Rodriguez-Tebar, A
  • Contacts between regenerating axons and the Schwann cells of sciatic nerve segments grafted to the optic nerve of adult rats
    Dezawa, M; Nagano, T
  • Prolonged delivery of BDNF by adenovirus-infected Müller cells temporarily rescues injured retinal ganglion cells
    Di Polo, A; Aigner, L.J; Dunn, R.J; Bray, G.M; Aguayo, A.J
  • Transforming growth factor alpha and its receptor in neural retina
    Fassio, J.B; Brockman, E.B; Jumblatt, M; Greaton, C; Henry, J.L; Geoghegan, T.E; Barr, C; Schultz, G.S
  • Basic fibroblast growth factor: receptor mediated internalization, metabolism, and anterograde axonal transport in retinal ganglion cells
    Ferguson, I.A; Schweitzer, J.B; Johnson, E.M
  • Immunohistochemical evidence for the distribution of nerve growth factor in the embryonic mouse
    Finn, P.J; Freguson, F.A; Wilson, P.A; Vahaviolos, J; Rush, R.A
  • BDNF down-regulates neurotrophin responsiveness, TrkB protein and TrkB mRNA levels in cultured rat hippocampal neurons
    Frank, L; Ventimiglia, R; Anderson, K; Lindsay, R.M; Rudge, J.S
  • Cells that express brain derived neurotrophic factor mRNA in the developing postnatal rat brain
    Friedman, W.J; Olson, L; Persson, H
    Bookmark
  • Ciliary neurotrophic factor promotes chick photoreceptor development in vitro
    Fuhrmann, S; Kirsch, M; Hofmann, H.D
  • Apoptosis in adult retinal ganglion cells after axotomy
    Garcia-Valenzuela, E; Gorczyca, W; Darzynkiewicz, Z; Sharma, S.C
  • Trophic factors produced by retinal cells increase the survival of retinal ganglion cells in vitro
    Giestal de Araujo, E; Linden, R
    Bookmark
  • Nogo in nerve regeneration
    Goldberg, J.L; Barres, B.A
  • Structural characterization and biological functions of fibroblast growth factor
    Gospodarowicz, D; Ferrara, N; Schweigerer, L; Neufeld, G
  • Retinal fate and ganglion cell differentiation are potentiated by acidic FGF in an in vitro assay of early retinal development
    Guillemot, F; Cepko, C.L
  • Changes in the distribution of insulin-like growth factor I, thioredoxin, thioredoxin reductase and ribonucleotide reductase during the development of the retina
    Hansson, H.A; Holmgren, A; Norstedt, G; Rozell, B
  • Biochemical studies on functional proteins in the brain nervous system. Neurobiochemical studies on nerve growth factor
    Hayashi, K
    Bookmark
  • Analysis of function and expression of the chick GPA receptor (GPAR alpha) suggests multiple roles in neuronal development
    Heller, S; Finn, T.P; Huber, J; Nishi, R; Geissen, M; Puschel, A.W; Rohrer, H
  • GDNF: a potent survival factor for motoneurons present in peripheral nerve and muscle
    Henderson, C.E; Phillips, H.S; Pollock, R.A; Davies, A.M; Lemeulle, C; Armanini, M; Simmons, L; Moffet, B; Vandlen, R.A; Simpson, L.C
  • Expression of the BDNF gene in the developing visual system of the chick
    Herzog, K.H; Bailey, K; Barde, Y.A
  • Alternating phases of FGF receptor and NGF receptor expression in the developing chick nervous system
    Heuer, J.G; von Bartheld, B.C; Kinoshita, Y; Evers, P.C; Bothwell, M
  • Fibroblast growth factors in the retina
    Hicks, D; Bugra, K; Faucheux, B
  • Regional distribution of brain-derived neurotrophic factor mRNA in the adult mouse brain
    Hofer, M; Pagliusi, S.R; Hohn, A; Leibrock, J; Barde, Y.A
  • Ciliary neuronotrophic factor stimulates choline acetyltransferase activity in cultured chicken retina neurons
    Hofmann, H.D
    Bookmark
  • Localization of p75 neurotrophin receptor in the retina of the adult SD rat: an immunocytochemical study at light and electron microscopic levels
    Hu, B; Yip, H.K; So, K.F
    Bookmark
  • The effects of early tectal lesions on development in the retinal ganglion cell layer of chick embryos
    Hughes, W.F; LaVelle, A
  • Ganglion cell death during normal retinal development in the chick: comparisons with cell death induced by early target field destruction
    Hughes, W.F; McLoon, S.C
  • Trophic effect of collicular proteoglycan on neonatal rat retinal ganglion cells in situ
    Huxlin, K.R; Carr, R; Schulz, M; Sefton, A.J; Bennett, M.R
  • Effect of collicular proteoglycan on the survival of adult rat retinal ganglion cells following axotomy
    Huxlin, K.R; Dreher, B; Schulz, M; Sefton, A.J; Bennett, M.R
    Bookmark
  • The alpha component of the CNTF receptor is required for signaling and defines potential CNTF targets in the adult and during development
    Ip, N.Y; McClain, J; Barrezueta, N.X; Aldrich, T.H; Pan, L; Li, Y; Wiegand, S.J; Friedman, B; Davis, S; Yancopoulos, G.D
  • The neurotrophins and CNTF: two families of collaborative neurotrophic factors
    Ip, N.Y; Yancopoulos, G.D
    Bookmark
  • Evidence for ganglion cell death during development of the ipsilateral retinal projection in the rat
    Jeffery, G; Perry, V.H
  • Different forms of the neurotrophin receptor trkB mRNA predominate in rat retina and optic nerve
    Jelsma, T.N; Friedman, H.H; Berkelaar, M; Bray, G.M; Aguayo, A.J
  • Ciliary neurotrophic factor is an axogenesis factor for retinal ganglion cells
    Jo, S.A; Wang, E; Benowitz, L.I
  • Brain derived neurotrophic factor supports the survival of cultured rat retinal ganglion cells
    Johnson, J.E; Barde, Y.A; Schwab, M; Thoenen, H
  • Expression of CNTF in Muller cells of the rat retina after pressure-induced ischemia
    Ju, W.K; Lee, M.Y; Hofmann, H.D; Kirsch, M; Chun, M.H
  • Expression of ciliary neurotrophic factor receptor mRNA and protein in the early postnatal and adult rat nervous system
    Kirsch, M; Hofmann, H.D
  • Evidence for multiple, local functions of ciliary neurotrophic factor (CNTF) in retinal development: expression of CNTF and its receptor and in vitro effects on target cells
    Kirsch, M; Lee, M.Y; Meyer, V; Wiese, A; Hofmann, H.D
  • In vivo neurotrophic effects of GDNF on axotomized retinal ganglion cells
    Klöcker, N; Braunling, F; Isenmann, S; Bahr, M
  • Free radical scavenging and inhibition of nitric oxide synthase potentiates the neurotrophic effects of brain-derived neurotrophic factor on axotomized retinal ganglion cells in vivo
    Klöcker, N; Cellerino, A; Bahr, M
  • Potentiated necrosis of cultured cortical neurons by neurotrophins
    Koh, J.Y; Gwag, B.J; Lobner, D; Choi, D.W
  • Localization of trkB and low-affinity nerve growth factor receptor mRNA in the developing rat retina
    Koide, T; Takahashi, J.B; Hoshimaru, M; Kojima, M; Otsuka, T; Asahi, M; Kikuchi, H
    Bookmark
  • Loss of axons from the optic nerve of the rat during early postnatal development
    Lam, K; Sefton, A.J; Bennett, M.R
  • Morphological changes of retinal ganglion cells regenerating axons along peripheral nerve grafts: a Lucifer Yellow and silver staining study
    Lau, K.C; So, K.F; Cho, E.Y
  • Intravitreal transplantation of a segment of peripheral nerve enhances axonal regeneration of retinal ganglion cells following distal axotomy
    Lau, K.C; So, K.F; Tay, D
  • Cellular localization of NGF and NT-3 mRNAs in postnatal rat forebrain
    Lauterborn, J.C; Issackson, P.J; Gall, C.M
  • Multiple growth factors, cytokines, and neurotrophins rescue photoreceptors from the damaging effects of constant light
    LaVail, M.M; Unoki, K; Yasumura, D
  • Coordinate expression of insulin-like growth factor system components by neurons and neuroglia during retinal and cerebellar development
    Lee, W.H; Javedan, S; Bondy, C.A
  • Survival of purified embryonic chick retinal ganglion cells in the presence of neurotrophic factors
    Lehwalder, D; Jefferey, P.L; Unsicker, K
    Bookmark
  • Morphological plasticity of axotomized retinal ganglion cells following intravitreal transplantation of a peripheral nerve segment
    Lei, J.L; Lau, K.C; So, K.F; Cho, E.Y; Tay, D
  • Molecular cloning and expression of brain-derived neurotrophic factor
    Leibrock, J; Lottspeich, F; Hohn, A; Hengerer, B; Masiakowski, P; Thoenen, H; Barde, Y.A
  • Differentiating effects of murine nerve growth factor in the peripheral and central nervous system of “ Xenopus laevis ” tadpoles
    Levi-Montalcini, R; Aloe, L
  • The role of fibroblasts and Schwann cells in promoting the survival of axotomized retinal ganglion cells
    Li, S.X; Yip, H.K; So, K.F
  • The role of transplanted Schwann cells in promoting regeneration of rat optic nerve
    Li, S.X; Yip, H.K; So, K.F
  • Purification, cloning, and expression of ciliary neurotrophic factor (CNTF)
    Lin, L.F; Mismer, D; Lile, J.D; Armes, L.G; Butler, E.T; Vannice, J.L; Collins, F
  • GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons
    Lin, L.F; Doherty, D.H; Lile, J.D; Bektesh, S; Collins, F
  • Acidic fibroblast growth factor enhances regeneration of processes by postnatal mammalian retinal ganglion cells in culture
    Lipton, S.A; Wagner, J.A; Madison, R.D; D’Amore, P.A
  • The effect of an intravitreal peripheral nerve graft on c-jun expression in regenerating retinal ganglion cells in hamsters
    Lu, Q; So, K.F; Yip, H.K
  • BDNF protein levels in developing hamster visual system
    Ma, Y.T; Hsieh, T; Forbes, M.E; Johnson, J.E; Frost, D.O
  • BDNF injected into the superior colliculus reduces developmental retinal ganglion cell death
    Ma, Y.T; Hsieh, T; Forbes, M.E; Johnson, J.E; Frost, D.O
  • CNTF receptor alpha mRNA expression in rodent cell lines and developing rat
    MacLennan, A.J; Gaskin, A.A; Lado, D.C
  • Schwann cells promote the survival of rat retinal ganglion cells after optic nerve section
    Maffei, L; Carmignoto, G; Perry, V.H; Candeo, P; Ferrari, G
  • NT-3, BDNF, and NGF in the developing rat nervous system: parallel as well as reciprocal patterns of expression
    Maisonpierre, P.C; Belluscio, L; Friedman, B; Alderson, R.F; Wiegand, S.J; Furth, M.E; Lindsay, R.M; Yancopoulos, G.D
  • NT-3 has a tropic effect on process outgrowth by postnatal auditory neurones in vitro
    Malgrange, G; Lefebvre, P.P; Martin, D; Staecker, H; Van de Water, T.R; Moonen, G
  • Effects of ocular injury and administration of brain-derived neurotrophic factor on survival and regrowth of axotomized retinal ganglion cells
    Mansour-robaey, S; Clarke, D.B; Wang, Y.C; Bray, G.M; Aguayo, A.J
  • Characterization of acidic and basic fibroblast growth factors in brain, retina, and vitreous chick embryo
    Mascarelli, F; Raulais, D; Counis, M.R; Courtois, Y
  • Recombinant human and rat ciliary neurotrophic factors
    Masiakowski, P; Liu, H.X; Radziejewski, C; Lottspeich, F; Oberthuer, W; Wong, V; Lindsay, R.M; Furth, M.E; Panayotatos, N
    Bookmark
  • The hematopoietic cytokine colony stimulating factor 1 is also a growth factor in the CNS: (II). Microencapsulated CSF-1 and LM-10 cells as delivery systems
    Maysinger, D; Derezovskaya, O; Fedoroff, S
    Bookmark
  • The survival of neonatal rat retinal ganglion cells in vitro is enhanced in the presence of appropriate parts of the brain
    McCaffery, C.A; Bennett, M.R; Dreher, B
    Bookmark
  • Effects of cultured astroglia on the survival of neonatal rat retinal ganglion cells in vitro
    McCaffrey, C.A; Raju, T.R; Bennett, M.R
  • Regeneration of ganglion cell axons in the adult mouse retina
    McDonnel, P; Berry, M
  • In vivo and in vitro effect of glucocorticoids on fibroblast growth factor (FGF)-2 and FGF receptor 1 expression
    Meisinger, C; Zeschnigk, C; Grothe, C
  • Intravitreal injections of neurotrophic factors support the survival of axotomized retinal ganglion cells in adult rats in vivo
    Mey, J; Thanos, S
  • Characterization of the signaling interactions that promote the survival and growth of developing retinal ganglion cells in culture
    Meyer-Franke, A; Kaplan, M.R; Pfrieger, F.W; Barres, B
  • Depolarization and camp elevation enhance responsiveness of CNS neurons to BDNF by recruiting TrkB to the plasma membrane
    Meyer-Franke, A; Wilkinson, G; Kruttgen, A; Hu, M; Munro, E; Hanson, M.G; Reichardt, L; Barres, B.A
  • Production of IGF-I and IGF binding proteins by retinal cells in vitro
    Moriarty, P; Boulton, M; Dickson, A; McLeod, D
  • Distribution of fibroblasts growth factor in cultured dorsal root ganglion neurons and Schwann cells
    Neuberger, T.J; De-Vires, G.H
  • Influence of peripheral nerve grafts on the expression of GAP-43 in regenerating retinal ganglion cells in adult hamsters
    Ng, T.F; So, K.F; Chung, S.K
  • Retinal ganglion cell survival in vitro maintained by a chondroitin sulfate proteoglycan from the superior colliculus carrying the HNK-1 epitope
    Nichol, K.A; Everett, A.W; Schulz, M; Bennett, M.R
    Bookmark
  • Neurotrophic factors: two are better than one
    Nishi, R
  • Embryonic chick retinal ganglion cells identified “ in vitro ”. Their survival is dependent on a factor from the optic tectum
    Nurcombe, V; Bennett, M.R
  • The effect of brain-derived neurotrophic factor on regeneration of nerve fibers after crush injury–morphometric evaluation
    Ohnishi, A; Yamamoto, T; Her, Q; Han, M; Murai, Y; Ikeda, M
  • Neuroprotection in relation to retinal ischemia and relevance to glaucoma
    Osborne, N.N; Ugarte, M; Chao, M; Chidlow, G; Bae, J.H; Wood, J.P.M; Nash, M.S
    Bookmark
  • Basic fibroblast growth factor induces retinal regeneration in vivo
    Park, C.M; Hollenberg, M.J
  • Further studies of the distribution of CDF/LIF mRNA
    Patterson, P.H; Fann, M.J
  • Effects of axotomy and intraocular administration of NT-4, NT-3, and brain-derived neurotrophic factor on the survival of adult rat retinal ganglion cells. A quantitative in vivo study
    Peinado-Ramon, P; Salvador, M; Villegas, P.M; Vidal, S.M
  • Expression of brain-derived neurotrophic factor and of its functional receptor in neonatal and adult rat retina
    Perez, M.T; Caminos, E
    Bookmark
  • Basic fibroblast growth factor induces retinal pigment epithelium to generate neural retina in vitro
    Pittack, C; Jones, M; Reh, T.A
  • Regeneration of rat optic axons into peripheral nerve grafts
    Politis, M.J; Spencer, P.S
  • The loss of ganglion cells in the developing retina of the rat
    Potts, R.A; Dreher, B; Bennett, M.R
  • Cell death and the elimination of retinal axons during development
    Provis, J.M; Penfold, P.L
  • Nerve growth factor reduces apoptosis of axotomized retinal ganglion cells in the neonatal rat
    Rabacchi, S.A; Ensini, M; Bonfanti, L; Gravina, A; Maffei, L
  • The localization and distribution of high affinity β -nerve growth factor binding in the central nervous system of the adult rat: a light microscopic auto-radiographic study using ( 125 I) β -nerve growth factor
    Raivich, G; Kreutzberg, G.W
  • Retinal ganglion cell survival and neurite regeneration in vitro after cell death period are dependent upon target derived trophic factor and retinal glial factor(s)
    Raju, T.R; Rao, M.S; Nagaraja, T.N; Meti, B.L; Schulz, M
  • Interleukin 6 in intact and injured mouse peripheral nerves
    Reichert, F; Levitzky, R; Rotshenker, S
    Bookmark
  • Expression of the proto-oncogene, trk, receptors in the developing rat retina
    Rickman, D.W; Brecha, N.C
  • The survival of chick retinal ganglion cells in response to brain derived neurotrophic factor depends on their embryonic age
    Rodriguez-Tebar, A; Jeffrey, P.L; Thoenen, H; Barde, Y.A
  • Neurotrophin-3 receptors in the developing chicken retina
    Rodriguez-Tebar, A; de la Rosa, E.J; Arribas, A
  • Differential expression of insulin-like growth factor genes in rat central nervous system
    Rotwein, P; Burgess, S.K; Milbrandt, J.D; Krause, J
  • Neuronal apoptosis in acute necrotic insults: why is this subject such a mess?
    Roy, M; Sapolsky, R
  • Epidermal growth factor and transforming growth factor alpha induce c-fos gene expression in retinal Muller cells in vivo
    Sagar, S.M; Edwards, R.H; Sharp, F.R
  • Nitric oxide mediates potentiation of neurotoxicity by neurotrophins
    Samdami, A; Newcamp, C; Resink, A; Facchinetti, F; Dawson, V.L; Dawson, T.M
  • Brain-derived neurotrophic factor and neurotrophin-4/5 stimulate growth of axonal branches from regenerating retinal ganglion cells
    Sawai, H; Clarke, D.B; Kittlerova, P; Bray, G.M; Aguayo, A.J
  • Expression of NGF receptor in the developing and adult primate central nervous system
    Schatteman, G.C; Gibbs, L; Lanahan, A.A; Claude, P; Bothwell, M
  • A retinal ganglion cell neurotrophic factor purified from the superior colliculus
    Schulz, M; Raju, T; Ralston, G; Bennett, M.R
    Bookmark
  • Early removal of one eye reduces normally occurring cell death in the remaining eye
    Sengelaub, D.R; Finlay, B.L
  • Retinal ganglion cells lose trophic responsiveness after axotomy
    Shen, S; Wiemelt, A.P; McMorris, F.A; Barres, B.A
  • Fibroblast growth factors promote the survival of adult rat retinal ganglion cells after transection of the optic nerve
    Sievers, J; Hausmann, B; Unsicker, K; Berry, M
  • Peripheral nerve grafts lacking viable Schwann cells fail to support central nervous system axonal regeneration
    Smith, G.V; Stevenson, J.A
    Bookmark
  • Lengthy regrowth of cut axons from ganglion cells after peripheral nerve transplantation into the retina of adult rats
    So, K.F; Aguayo, A.J
  • The effect of damage of the brachium of the superior colliculus in neonatal and adult hamsters and the use of peripheral nerve to restore retinocollicular projections
    So, K.F; Sawai, H; Ireland, S; Tay, D; Fukuda, Y
  • Effects on the growth of damaged ganglion cell axons after peripheral nerve transplantation in adult hamsters
    So, K.F; Xiao, Y.M; Diao, Y.C
  • Regenerative capacity of retinal ganglion cells in mammals
    So, K.F; Yip, H.K
    Bookmark
  • CNTF induced axonal re-growth across the crush site of the optic nerve
    So, K.F; Zeng, Q.R; Yip, H.K; Cho, K.S
  • The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor
    Soppet, D; Escandon, E; Maragos, J; Middlemas, D.S; Reid, S.W; Blair, J; Burton, L.E; Stanton, B.R; Kaplan, D.R; Hunter, T
  • trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor
    Squinto, S.P; Stitt, T.N; Aldrich, T.H; Davis, S; Bianco, S.M; Radziejewski, C; Glass, D.J; Masiakowski, P; Furth, M.E; Valenzuela, D.M
  • Molecular cloning, expression and regional distribution of rat ciliary neurotrophic factor
    Stockli, K.A; Lottspeich, F; Sendtner, M; Masiakowski, P; Carroll, P; Gotz, R; Lindholm, D; Thoenen, H
  • Regional distribution, developmental changes, and cellular localization of CNTF-mRNA and protein in the rat brain
    Stockli, K.A; Lillien, L.E; Naher-Noe, M; Breitfeld, G; Hughes, R.A; Raff, M.C; Thoenen, H; Sendtner, M
    Bookmark
  • Developmental expression of trkB and low-affinity NGF receptor in the rat retina
    Takahashi, J.B; Hoshimaru, M; Kikuchi, H; Hatanaka, M
  • Survival and axonal elongation of adult rat retinal ganglion cells: in vitro effects of lesioned sciatic nerve and brain derived neurotrophic factor (BDNF)
    Thanos, S; Bahr, M; Barde, Y.A; Vanselow, J
  • The role of growth factors in the embryogenesis and differentiation of the eye
    Tripathi, B.J; Tripathi, R.C; Livingston, A.M; Borisuth, N.S
  • Peripheral expression and biological activities of GDNF, a new neurotrophic factor for avian and mammalian peripheral neurons
    Trupp, M; Ryden, M; Jornvall, H; Funakoshi, H; Timmusk, T; Arenas, E; Ibanez, C.F
    Bookmark
  • TrkA, TrkB and p75 mRNA expression is developmentally regulated in the rat retina
    Ugolini, G; Cremisi, F; Maffei, L
    Bookmark
  • Protection of the rat retina from ischemic injury by brain-derived neurotrophic factor, ciliary neurotrophic factor, and basic fibroblast growth factor
    Unoki, K; LaVail, M.M
  • Axonal regeneration and synapse formation in the superior colliculus by retinal ganglion cells in the adult rat
    Vidal-Sanz, M; Bray, G.M; Villegas-Perez, M; Thanos, S; Aguayo, A.J
  • Rapid and protracted phases of retinal ganglion cell loss follow axotomy in the optic nerve of adult rats
    Villegas, P.M; Vidal, S.M; Rasminsky, M; Bray, G.M; Aguayo, A.J
  • Insulin and IGF-I binding in developing chick neural retina and pigment epithelium: a characterization of binding and structural differences
    Waldbillig, R.J; Arnold, D.R; Fletcher, R.T; Chader, G.J
  • Expression of FGF receptor gene in rat development
    Wanaka, A; Milbrandt, J; Johnson, E.J
  • Spontaneously immortalized adult mouse Schwann cells secrete autocrine and paracrine growth-promoting activities
    Watabe, K; Fukuda, T; Tanaka, J; Honda, H; Toyohara, K; Sakai, O
    Bookmark
  • Morphology of retinal ganglion cells that regenerated axons along peripheral nerve graft in cats
    Watanabe, M; Sawai, H; Fukuda, Y
  • Injury-induced upregulation of bFGF and CNTF mRNAS in the rat retina
    Wen, R; Song, Y; Cheng, T; Matthes, M.T; Yasumura, D; LaVail, M.M; Steinberg, R.H
  • Localization of brain-derived neurotrophic factor mRNA to neurons in the brain by in situ hybridization
    Wetmore, C; Ernfors, P; Persson, H; Olson, L
  • Localization of cholinergic differentiation factor/leukemia inhibitory factor in the rat brain and peripheral tissues
    Yamamori, T
  • An immunohistochemical study of the nerve growth factor receptor in developing rats
    Yan, Q; Johnson, E.M
  • Immunohistochemical localization and biochemical characterization of nerve growth receptor in adult rat brain
    Yan, Q; Johnson, E.M
  • Glial cell line-derived neurotrophic factor (GDNF) promotes the survival of axotomized retinal ganglion cells in adult rats: comparison to and combination with brain-derived neurotrophic factor (BDNF)
    Yan, Q; Wang, J; Matheson, C.R; Urich, J.L
  • Chondroitinase ABC promotes axonal regeneration of Clarke’s neurons after spinal cord injury
    Yick, L.-W; Wu, W.T; So, K.-F; Yip, H.K; Shum, D.K.Y
  • The effect of intravitreal peripheral nerve on axonal regeneration following the crush injury of the optic nerve
    Zeng, Q.R; So, K.F; Yip, H.K
  • Differential effects of bFGF on development of the rat retina
    Zhao, S; Barnstable, C.J
    Bookmark

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