Axonal regeneration of retinal ganglion cells: effect of trophic factors

Axonal regeneration of retinal ganglion cells: effect of trophic factors A variety of neurotrophic factors can influence the cell functions of the developing, mature and injured retinal ganglion cells. The discovery that retinal ganglion cell loss can be alleviated by neurotrophic factors has generated a great deal of interest in the therapeutic potential of these molecules. Recently, evidence has provided valuable information on the receptors that mediate these events and the intracellular signaling cascades after the binding of these ligands. Signaling by neurotrophic factors does not seem to restrict to retrograde messenger from the target but also includes local interactions with neighbouring cells along the axonal pathways, anterograde signaling from the afferents and autocrine signaling. More insight into the mechanisms of action of neurotrophic factors and the signal transduction pathway leading to the protection and regeneration of retinal ganglion cells may allow the design of new therapeutic strategies. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Progress in Retinal and Eye Research Elsevier

Axonal regeneration of retinal ganglion cells: effect of trophic factors

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Publisher
Elsevier
Copyright
Copyright © 2000 Elsevier Science Ltd
ISSN
1350-9462
eISSN
1873-1635
D.O.I.
10.1016/S1350-9462(00)00009-4
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Abstract

A variety of neurotrophic factors can influence the cell functions of the developing, mature and injured retinal ganglion cells. The discovery that retinal ganglion cell loss can be alleviated by neurotrophic factors has generated a great deal of interest in the therapeutic potential of these molecules. Recently, evidence has provided valuable information on the receptors that mediate these events and the intracellular signaling cascades after the binding of these ligands. Signaling by neurotrophic factors does not seem to restrict to retrograde messenger from the target but also includes local interactions with neighbouring cells along the axonal pathways, anterograde signaling from the afferents and autocrine signaling. More insight into the mechanisms of action of neurotrophic factors and the signal transduction pathway leading to the protection and regeneration of retinal ganglion cells may allow the design of new therapeutic strategies.

Journal

Progress in Retinal and Eye Research – Elsevier

Published: Sep 1, 2000

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    Smith, G.V; Stevenson, J.A
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  • Lengthy regrowth of cut axons from ganglion cells after peripheral nerve transplantation into the retina of adult rats
    So, K.F; Aguayo, A.J
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  • Regenerative capacity of retinal ganglion cells in mammals
    So, K.F; Yip, H.K
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  • The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor
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    Takahashi, J.B; Hoshimaru, M; Kikuchi, H; Hatanaka, M
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    Ugolini, G; Cremisi, F; Maffei, L
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    Unoki, K; LaVail, M.M
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    Wanaka, A; Milbrandt, J; Johnson, E.J
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    Watanabe, M; Sawai, H; Fukuda, Y
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  • Chondroitinase ABC promotes axonal regeneration of Clarke’s neurons after spinal cord injury
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