Aversive effects of the synthetic cannabinoid CP 55,940 in rats

Aversive effects of the synthetic cannabinoid CP 55,940 in rats A series of experiments investigated the behavioral and hedonic effects of the synthetic cannabinoid CP 55,940 in male Wistar rats. CP 55,940 had a biphasic effect on locomotor activity, with a 10 μg/kg dose causing locomotor stimulation and a 100 μg/kg dose causing profound hypoactivity. CP 55,940 (100 μg/kg) also caused a marked hypothermia for at least 3 h following administration, while lower doses (2.5 and 10 μg/kg) had no effect. CP 55,940 (100 gmg/kg) had anorexic and hyperdipsic effects for up to 24 h following administration and caused significant reductions in body weight. CP 55,940 (100 μg/kg) also caused significant avoidance to a flavoured fluid (saccharin) with which it was paired. In the conditioned place preference paradigm both the 10 μg/kg and 100 μg/kg doses of CP 55,940 produced significant place avoidance. It is concluded that CP 55,940 is aversive to rats. The possible mechanisms underlying this aversion are discussed. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Pharmacology Biochemistry and Behavior Elsevier

Aversive effects of the synthetic cannabinoid CP 55,940 in rats

Loading next page...
 
/lp/elsevier/aversive-effects-of-the-synthetic-cannabinoid-cp-55-940-in-rats-ScrZ9gXL0h
Publisher
Elsevier
Copyright
Copyright © 1996 Elsevier Ltd
ISSN
0091-3057
eISSN
1873-5177
D.O.I.
10.1016/0091-3057(95)02066-7
Publisher site
See Article on Publisher Site

Abstract

A series of experiments investigated the behavioral and hedonic effects of the synthetic cannabinoid CP 55,940 in male Wistar rats. CP 55,940 had a biphasic effect on locomotor activity, with a 10 μg/kg dose causing locomotor stimulation and a 100 μg/kg dose causing profound hypoactivity. CP 55,940 (100 μg/kg) also caused a marked hypothermia for at least 3 h following administration, while lower doses (2.5 and 10 μg/kg) had no effect. CP 55,940 (100 gmg/kg) had anorexic and hyperdipsic effects for up to 24 h following administration and caused significant reductions in body weight. CP 55,940 (100 μg/kg) also caused significant avoidance to a flavoured fluid (saccharin) with which it was paired. In the conditioned place preference paradigm both the 10 μg/kg and 100 μg/kg doses of CP 55,940 produced significant place avoidance. It is concluded that CP 55,940 is aversive to rats. The possible mechanisms underlying this aversion are discussed.

Journal

Pharmacology Biochemistry and BehaviorElsevier

Published: Mar 1, 1996

References

  • Reluctance of rats to drink hashish suspensions: Free-choice and forced consumption, and the effects of hypothalamic stimulation
    Corocoran, M.E.; Amit, Z.

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off