Autophagy Inhibition in Pancreatic Adenocarcinoma

Autophagy Inhibition in Pancreatic Adenocarcinoma Although some progress has been made in recent years with the development of more effective chemotherapy regimens, new treatment approaches are needed to improve outcomes for patients with pancreatic adenocarcinoma. The cellular process of autophagy, a cell survival mechanism that allows cancer cells to survive the hazardous conditions of the tumor microenvironment and treatment, has emerged as a viable target in pancreatic cancer. We review the mechanism of autophagy, its role in pancreatic carcinogenesis, the preclinical and clinical evidence supporting targeting autophagy in patients with pancreatic adenocarcinoma, and areas of future investigation that hold promise for improving this treatment approach. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinical Colorectal Cancer Elsevier

Autophagy Inhibition in Pancreatic Adenocarcinoma

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Publisher
Elsevier
Copyright
Copyright © 2017 Elsevier Inc.
ISSN
1533-0028
eISSN
1936-0674
D.O.I.
10.1016/j.clcc.2017.10.013
Publisher site
See Article on Publisher Site

Abstract

Although some progress has been made in recent years with the development of more effective chemotherapy regimens, new treatment approaches are needed to improve outcomes for patients with pancreatic adenocarcinoma. The cellular process of autophagy, a cell survival mechanism that allows cancer cells to survive the hazardous conditions of the tumor microenvironment and treatment, has emerged as a viable target in pancreatic cancer. We review the mechanism of autophagy, its role in pancreatic carcinogenesis, the preclinical and clinical evidence supporting targeting autophagy in patients with pancreatic adenocarcinoma, and areas of future investigation that hold promise for improving this treatment approach.

Journal

Clinical Colorectal CancerElsevier

Published: Mar 1, 2018

References

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