Autophagy and MHC-restricted antigen presentation

Autophagy and MHC-restricted antigen presentation •Autophagy is a conserved cellular process regulated by immunological cues.•Autophagy is used to process self and viral antigens restricted by MHC II molecules.•Autophagy activity in immunocytes is a tolerogenic and anti-inflammatory process.•Autophagy control the levels of intracellular pro-inflammatory signalling molecules and damaged ROS producing mitochondria.•Mutations in molecules involved in autophagy are susceptibility markers for inflammatory diseases. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Molecular Immunology Elsevier

Autophagy and MHC-restricted antigen presentation

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Publisher
Elsevier
Copyright
Copyright © 2018 Elsevier Ltd
ISSN
0161-5890
D.O.I.
10.1016/j.molimm.2018.05.009
Publisher site
See Article on Publisher Site

Abstract

•Autophagy is a conserved cellular process regulated by immunological cues.•Autophagy is used to process self and viral antigens restricted by MHC II molecules.•Autophagy activity in immunocytes is a tolerogenic and anti-inflammatory process.•Autophagy control the levels of intracellular pro-inflammatory signalling molecules and damaged ROS producing mitochondria.•Mutations in molecules involved in autophagy are susceptibility markers for inflammatory diseases.

Journal

Molecular ImmunologyElsevier

Published: Jul 1, 2018

References

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