Auto-catalytic ceria nanoparticles offer neuroprotection to adult rat spinal cord neurons

Auto-catalytic ceria nanoparticles offer neuroprotection to adult rat spinal cord neurons This paper describes the evaluation of the auto-catalytic anti-oxidant behavior and biocompatibility of cerium oxide nanoparticles for applications in spinal cord repair and other diseases of the central nervous system. The application of a single dose of nano-ceria at a nano-molar concentration is biocompatible, regenerative and provides a significant neuroprotective effect on adult rat spinal cord neurons. Retention of neuronal function is demonstrated from electrophysiological recordings and the possibility of its application to prevent ischemic insult is suggested from an oxidative injury assay. A mechanism is proposed to explain the auto-catalytic properties of these nanoparticles. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Biomaterials Elsevier

Auto-catalytic ceria nanoparticles offer neuroprotection to adult rat spinal cord neurons

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Publisher
Elsevier
Copyright
Copyright © 2006 Elsevier Ltd
ISSN
0142-9612
D.O.I.
10.1016/j.biomaterials.2006.11.036
Publisher site
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Abstract

This paper describes the evaluation of the auto-catalytic anti-oxidant behavior and biocompatibility of cerium oxide nanoparticles for applications in spinal cord repair and other diseases of the central nervous system. The application of a single dose of nano-ceria at a nano-molar concentration is biocompatible, regenerative and provides a significant neuroprotective effect on adult rat spinal cord neurons. Retention of neuronal function is demonstrated from electrophysiological recordings and the possibility of its application to prevent ischemic insult is suggested from an oxidative injury assay. A mechanism is proposed to explain the auto-catalytic properties of these nanoparticles.

Journal

BiomaterialsElsevier

Published: Apr 1, 2007

References

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