Audiogenic seizures following global ischemia induced by chest compression in Long-Evans rats

Audiogenic seizures following global ischemia induced by chest compression in Long-Evans rats Transient global ischemia was used to produce a rat model of generalized tonic-clonic epilepsy. Controlled chest compression in ketamine-anesthesized Long-Evans rats produced transient global ischemia by mechanically preventing the heart from pumping blood. Circulation was restored by standard cardiopulmonary resuscitation techniques. With a temporal muscle (skull) temperature of 35 ± 0.4°C, 75% (76/102) of the rats survived 7 min of chest compression. Generalized seizures could be evoked in 78% (59/76) of the surviving rats by a 60 s exposure to a loud sound (bell, 110 dB) beginning 24 h after the ischemic episode. The seizure patterns seen resembled those described by Maresceaux (1987) for genetically seizure-prone Wistar rats. Susceptibility to sound-induced seizures declined with time, with wide variations in recovery rate between individuals; one rat showed a daily sound-induced seizure for over 5 months. Seizures were attenuated or blocked by treatment with carbamazepine or sodium valproate. This model is similar to the great vessel occlusion model used by Kawai et al. (1995), but is less invasive. We believe it will be useful in the evaluation of therapies for acquired generalized (grand mal) seizures. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Epilepsy Research Elsevier

Audiogenic seizures following global ischemia induced by chest compression in Long-Evans rats

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Publisher
Elsevier
Copyright
Copyright © 1996 Elsevier Ltd
ISSN
0920-1211
D.O.I.
10.1016/0920-1211(95)00099-2
Publisher site
See Article on Publisher Site

Abstract

Transient global ischemia was used to produce a rat model of generalized tonic-clonic epilepsy. Controlled chest compression in ketamine-anesthesized Long-Evans rats produced transient global ischemia by mechanically preventing the heart from pumping blood. Circulation was restored by standard cardiopulmonary resuscitation techniques. With a temporal muscle (skull) temperature of 35 ± 0.4°C, 75% (76/102) of the rats survived 7 min of chest compression. Generalized seizures could be evoked in 78% (59/76) of the surviving rats by a 60 s exposure to a loud sound (bell, 110 dB) beginning 24 h after the ischemic episode. The seizure patterns seen resembled those described by Maresceaux (1987) for genetically seizure-prone Wistar rats. Susceptibility to sound-induced seizures declined with time, with wide variations in recovery rate between individuals; one rat showed a daily sound-induced seizure for over 5 months. Seizures were attenuated or blocked by treatment with carbamazepine or sodium valproate. This model is similar to the great vessel occlusion model used by Kawai et al. (1995), but is less invasive. We believe it will be useful in the evaluation of therapies for acquired generalized (grand mal) seizures.

Journal

Epilepsy ResearchElsevier

Published: Apr 1, 1996

References

  • Genetic models of epilepsies
    Jobe, P.C.; Mishra, P.K.; Ludvig, N.; Dailey, J.W.
  • Clinical restitution following cerebral ischemia in hypo-, normo- and hyperglycemic rats
    Siemkowicz, E.; Hansen, A.J.
  • Models for studying long-term recovery following forebrain ischemia in the rat. 2. A 2-vessel occlusion model
    Smith, M.L.; Bendek, G.; Dahlgren, N.; Rosen, I.; Wieloch, T.; Siesjo, B.K.

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