Attenuation of spontaneous opiate withdrawal in mice by the anandamide transport inhibitor AM404

Attenuation of spontaneous opiate withdrawal in mice by the anandamide transport inhibitor AM404 The endogenous cannabinoid, anandamide, has been shown to attenuate naloxone-precipitated opiate withdrawal in rodents. Here we show that the spontaneous, but not the naloxone-precipitated withdrawal syndrome in morphine-dependent mice is attenuated by the inhibitor of carrier-mediated anandamide transport N -(4-hydroxyphenyl) arachidonylethanolamide (AM404) (2 and 10 mg/kg, i.p.). These results suggest that spontaneous but not opioid antagonist-precipitated withdrawal is associated with dynamic changes in endogenous cannabinoid signaling. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Pharmacology Elsevier

Attenuation of spontaneous opiate withdrawal in mice by the anandamide transport inhibitor AM404

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Publisher
Elsevier
Copyright
Copyright © 2002 Elsevier Science B.V.
ISSN
0014-2999
D.O.I.
10.1016/S0014-2999(02)02483-4
Publisher site
See Article on Publisher Site

Abstract

The endogenous cannabinoid, anandamide, has been shown to attenuate naloxone-precipitated opiate withdrawal in rodents. Here we show that the spontaneous, but not the naloxone-precipitated withdrawal syndrome in morphine-dependent mice is attenuated by the inhibitor of carrier-mediated anandamide transport N -(4-hydroxyphenyl) arachidonylethanolamide (AM404) (2 and 10 mg/kg, i.p.). These results suggest that spontaneous but not opioid antagonist-precipitated withdrawal is associated with dynamic changes in endogenous cannabinoid signaling.

Journal

European Journal of PharmacologyElsevier

Published: Nov 1, 2002

References

  • Anandamide decreases naloxone-precipitated withdrawal signs in mice treated chronically with morphine
    Vela, G.; Ruiz Gayo, M.; Fuentes, J.A.

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