Attenuation of retinal photooxidative damage in thioredoxin transgenic mice

Attenuation of retinal photooxidative damage in thioredoxin transgenic mice Thioredoxin (TRX) is an endogenous redox (reduction/oxidation) regulator that has cytoprotective effects against various types of oxidative stresses. Exposure to excessive levels of white light induces retinal photoreceptor damage. To test the cytoprotective effect of overexpressed TRX against retinal photooxidative damage, both TRX transgenic (trx-tg) mice and C57BL/6 (wild type) mice were exposed to intense white fluorescent light. The amounts of oxidized and tyrosine-phosphorylated proteins decreased in the neural retinas of the trx-tg mice compared to the wild type mice after light exposure. The electroretinographic amplitudes were higher and the formation of oxidized DNA was lower in trx-tg mice compared to wild type mice after light exposure. These results suggest that overexpression of TRX suppresses retinal photooxidative damage. TRX intensification may be a useful therapeutic strategy to prevent retinal photic injury. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Neuroscience Letters Elsevier

Attenuation of retinal photooxidative damage in thioredoxin transgenic mice

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Publisher
Elsevier
Copyright
Copyright © 2002 Elsevier Ltd
ISSN
0304-3940
D.O.I.
10.1016/S0304-3940(02)00314-2
Publisher site
See Article on Publisher Site

Abstract

Thioredoxin (TRX) is an endogenous redox (reduction/oxidation) regulator that has cytoprotective effects against various types of oxidative stresses. Exposure to excessive levels of white light induces retinal photoreceptor damage. To test the cytoprotective effect of overexpressed TRX against retinal photooxidative damage, both TRX transgenic (trx-tg) mice and C57BL/6 (wild type) mice were exposed to intense white fluorescent light. The amounts of oxidized and tyrosine-phosphorylated proteins decreased in the neural retinas of the trx-tg mice compared to the wild type mice after light exposure. The electroretinographic amplitudes were higher and the formation of oxidized DNA was lower in trx-tg mice compared to wild type mice after light exposure. These results suggest that overexpression of TRX suppresses retinal photooxidative damage. TRX intensification may be a useful therapeutic strategy to prevent retinal photic injury.

Journal

Neuroscience LettersElsevier

Published: Jun 28, 2002

References

  • Thioredoxin, a singlet oxygen quencher and hydroxyl radical scavenger: redox independent functions
    Das, K.C.; Das, C.K.
  • Redox regulation of cellular activation
    Nakamura, H.; Nakamura, K.; Yodoi, J.
  • Light damage in the rat retina: effect of a radioprotective agent (WR-77913) on acute rod outer segment disk disruptions
    Reme, C.E.; Braschler, U.F.; Roberts, J.; Dillon, J.
  • Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1
    Saitoh, M.; Nishitoh, H.; Fujii, M.; Takeda, K.; Tobiume, K.; Sawada, Y.; Kawabata, M.; Miyazono, K.; Ichijo, H.

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