Atherosclerosis is an inflammatory disease

Atherosclerosis is an inflammatory disease Examination of the earliest cellular events that occur during atherogenesis has demonstrated a specialized type of chronic inflammatory response that precedes migration and proliferation of arterial smooth muscle cells. The first observable events include increased accumulation of lipid and lipoprotein particles beneath the endothelium, presumably from increased transport and/or permeability of the lining endothelial cells. This event is rapidly followed by attachment, adherence, and spreading of peripheral blood monocytes and T-lymphocytes at sites throughout the arterial tree, particularly at branches and bifurcations. These cells adhere from the formation of adhesive cell-surface glycoproteins by the endothelium and the leukocytes, which interact in a ligand-receptor manner. Thus one of the earliest changes induced by hypercholesterolemia and hypertension appears to be altered endothelial permeability, together with the adherence of leukocytes, representing the first phase of an inflammatory response. The leukocytes migrate across the surface of the endothelium, probe between the junctions of the endothelial cells, and are chemotactically attracted into the subendothelial space where they begin to accumulate within the intima. In the presence of oxidized low-density lipoprotein, the monocytes become converted to activated macrophages and, through their scavenger receptors, take up the modified lipoprotein particles and become foam cells. The http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Heart Journal Elsevier

Atherosclerosis is an inflammatory disease

American Heart Journal, Volume 138 (5) – Nov 1, 1999

Loading next page...
 
/lp/elsevier/atherosclerosis-is-an-inflammatory-disease-KwYee0bxaP
Publisher
Elsevier
Copyright
Copyright © 1999 Mosby, Inc.
ISSN
0002-8703
D.O.I.
10.1016/S0002-8703(99)70266-8
Publisher site
See Article on Publisher Site

Abstract

Examination of the earliest cellular events that occur during atherogenesis has demonstrated a specialized type of chronic inflammatory response that precedes migration and proliferation of arterial smooth muscle cells. The first observable events include increased accumulation of lipid and lipoprotein particles beneath the endothelium, presumably from increased transport and/or permeability of the lining endothelial cells. This event is rapidly followed by attachment, adherence, and spreading of peripheral blood monocytes and T-lymphocytes at sites throughout the arterial tree, particularly at branches and bifurcations. These cells adhere from the formation of adhesive cell-surface glycoproteins by the endothelium and the leukocytes, which interact in a ligand-receptor manner. Thus one of the earliest changes induced by hypercholesterolemia and hypertension appears to be altered endothelial permeability, together with the adherence of leukocytes, representing the first phase of an inflammatory response. The leukocytes migrate across the surface of the endothelium, probe between the junctions of the endothelial cells, and are chemotactically attracted into the subendothelial space where they begin to accumulate within the intima. In the presence of oxidized low-density lipoprotein, the monocytes become converted to activated macrophages and, through their scavenger receptors, take up the modified lipoprotein particles and become foam cells. The

Journal

American Heart JournalElsevier

Published: Nov 1, 1999

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off