Associations of elevated Interleukin-6 and C-Reactive protein levels with mortality in the elderly ∗ ∗ Access the “Journal Club” discussion of this paper at http:/www.elsevier.com/locate/ajmselect/

Associations of elevated Interleukin-6 and C-Reactive protein levels with mortality in the... PURPOSE: To investigate whether interleukin-6 and C-reactive protein levels predict all-cause and cause-specific mortality in a population-based sample of nondisabled older people. SUBJECTS AND METHODS: A sample of 1,293 healthy, nondisabled participants in the Iowa 65+ Rural Health Study was followed prospectively for a mean of 4.6 years. Plasma interleukin-6 and C-reactive protein levels were measured in specimens obtained from 1987 to 1989. RESULTS: Higher interleukin-6 levels were associated with a twofold greater risk of death (relative risk (RR) for the highest quartile (≥3.19 pg/mL) compared with the lowest quartile of 1.9 (95% confidence interval, CI, 1.2 to 3.1)). Higher C-reactive protein levels (≥2.78 mg/L) were also associated with increased risk (RR = 1.6; CI, 1.0 to 2.6). Subjects with elevation of both interleukin-6 and C-reactive protein levels were 2.6 times more likely (CI, 1.6 to 4.3) to die during follow-up than those with low levels of both measurements. Similar results were found for cardiovascular and noncardiovascular causes of death, as well as when subjects were stratified by sex, smoking status, and prior cardiovascular disease, and for both early (<2.3 years) and later follow-up. Results were independent of age, sex, body mass index, and history of smoking, diabetes, and cardiovascular disease, as well as known indicators of inflammation including fibrinogen and albumin levels and white blood cell count. CONCLUSIONS: Higher circulating levels of interleukin-6 and C-reactive protein were associated with mortality in this population-based sample of healthy older persons. These measures may be useful for identification of high-risk subgroups for anti-inflammatory interventions. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The American Journal of Medicine Elsevier

Associations of elevated Interleukin-6 and C-Reactive protein levels with mortality in the elderly ∗ ∗ Access the “Journal Club” discussion of this paper at http:/www.elsevier.com/locate/ajmselect/

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Publisher
Elsevier
Copyright
Copyright © 1999 Excerpta Medica Inc.
ISSN
0002-9343
D.O.I.
10.1016/S0002-9343(99)00066-2
Publisher site
See Article on Publisher Site

Abstract

PURPOSE: To investigate whether interleukin-6 and C-reactive protein levels predict all-cause and cause-specific mortality in a population-based sample of nondisabled older people. SUBJECTS AND METHODS: A sample of 1,293 healthy, nondisabled participants in the Iowa 65+ Rural Health Study was followed prospectively for a mean of 4.6 years. Plasma interleukin-6 and C-reactive protein levels were measured in specimens obtained from 1987 to 1989. RESULTS: Higher interleukin-6 levels were associated with a twofold greater risk of death (relative risk (RR) for the highest quartile (≥3.19 pg/mL) compared with the lowest quartile of 1.9 (95% confidence interval, CI, 1.2 to 3.1)). Higher C-reactive protein levels (≥2.78 mg/L) were also associated with increased risk (RR = 1.6; CI, 1.0 to 2.6). Subjects with elevation of both interleukin-6 and C-reactive protein levels were 2.6 times more likely (CI, 1.6 to 4.3) to die during follow-up than those with low levels of both measurements. Similar results were found for cardiovascular and noncardiovascular causes of death, as well as when subjects were stratified by sex, smoking status, and prior cardiovascular disease, and for both early (<2.3 years) and later follow-up. Results were independent of age, sex, body mass index, and history of smoking, diabetes, and cardiovascular disease, as well as known indicators of inflammation including fibrinogen and albumin levels and white blood cell count. CONCLUSIONS: Higher circulating levels of interleukin-6 and C-reactive protein were associated with mortality in this population-based sample of healthy older persons. These measures may be useful for identification of high-risk subgroups for anti-inflammatory interventions.

Journal

The American Journal of MedicineElsevier

Published: May 1, 1999

References

  • Proinflammatory cytokine levels in patients with depressed left ventricular ejection fraction
    Torre-Amione, G; Kapadia, S; Benedict, C; Oral, H; Young, J.B; Mann, D.L
  • C-reactive protein levels as a direct indicator of interleukin-6 levels in humans in vivo
    Bataille, R; Klein, B
  • Established populations for epidemiologic studies of the elderly
    Cornoni-Huntley, J; Ostfeld, A.M; Taylor, J.A
  • Variability in the measurement of C-reactive protein in healthy subjects
    Macy, E.M; Hayes, T.E; Tracy, R.P
  • Elimination of interleukin-6 attenuates coagulation activation in experimental endotoxemia in chimpanzees
    Van der Poll, T; Levi, M; Hack, C.E
  • The association of plasma IL-6 levels with functional disability in community-dwelling elderly
    Cohen, H.J; Pieper, C.F; Harris, T.B; Rao, K.M.K; Currie, M.S

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