Throughout the 20th century, many researchers focused their interest on prevention and therapy of cardiovascular diseases. Among the factors that may influence the occurrence of disease is the beneficial effect of physical activity, which has been discussed in several studies. 1–3 In addition, recent studies have provided evidence that inflammation plays a role in the pathogenesis of cardiovascular disease. 4,5 Several investigators have addressed the association between fitness and the inflammation process, 6–9 but the strength of this relation has not been fully investigated. The aim of this study is to evaluate the effect of various levels of leisure-time physical activity on inflammation markers, such as high-sensitivity C-reactive protein (CRP), fibrinogen, amyloid A, and white blood cell (WBC) counts, in a population-based sample of healthy adults. The ATTICA study is a health and nutrition cross-sectional survey that was carried out in the province of Attica from 2001 to 2002. A sample of 891 men and 965 women, aged >18 years old, was drawn from the general population, which excluded persons living in institutions, or subjects with mobility problems or who had chronic disease that could restrict their physical activity status (e.g., arthritis). Also, all subjects entered into this
The American Journal of Cardiology – Elsevier
Published: Feb 1, 2003
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