•Diabetes mellitus impairs somatic thermal sensation to noxious stimulation.•Reduction of CGRP and substance P in DRG innervating the heart was detected in diabetic rats.•CGRP and substance P in myocardium were reduced in diabetic animals at rest or in ischemia/reperfusion.•Increases of infarction size and myocyte apoptosis were observed in diabetic animals.•CGRP and substance P inhibit myocyte injury induced by high glucose and hypoxia/reoxygenation.
Peptides – Elsevier
Published: Oct 1, 2017
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