Applicability of [11C]PIB micro-PET imaging for in vivo follow-up of anti-amyloid treatment effects in APP23 mouse model

Applicability of [11C]PIB micro-PET imaging for in vivo follow-up of anti-amyloid treatment... In this study, we evaluated the anti-amyloid effect of functionalized nanoliposomes (mApoE-PA-LIP) in a mouse model of Alzheimer's disease with use of positron emission tomography and β-amyloid (Aβ)–targeted tracer [11C]Pittsburgh compound B ([11C]PIB). APP23 mice were injected with mApoE-PA-LIP or saline (3 times per week for 3 weeks) and [11C]PIB imaging was performed at baseline, after the treatment and after 3 months follow-up period, accompanied by Aβ immunohistochemistry and ELISA. After the treatment, [11C]PIB binding ratios between mApoE-PA-LIP and saline groups were equivalent in all analyzed brain regions; however, in the saline group, binding ratios increased from the baseline, whereas no increase was detected in the mApoE-PA-LIP group. During the additional follow-up, [11C]PIB binding increased significantly from baseline in both groups, and binding ratios correlated with the immunohistochemically defined Aβ load. This study further supports the use of [11C]PIB positron emission tomography imaging as a biomarker of Aβ deposition in APP23 mice and highlights the benefits of noninvasive follow-up, that is, using baseline data for animal stratification and normalization of treatment effects to baseline values, for future anti-amyloid treatment studies. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Neurobiology of Aging Elsevier

Applicability of [11C]PIB micro-PET imaging for in vivo follow-up of anti-amyloid treatment effects in APP23 mouse model

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Publisher
Elsevier
Copyright
Copyright © 2017 The Authors
ISSN
0197-4580
DOI
10.1016/j.neurobiolaging.2017.05.008
pmid
28605642
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Abstract

In this study, we evaluated the anti-amyloid effect of functionalized nanoliposomes (mApoE-PA-LIP) in a mouse model of Alzheimer's disease with use of positron emission tomography and β-amyloid (Aβ)–targeted tracer [11C]Pittsburgh compound B ([11C]PIB). APP23 mice were injected with mApoE-PA-LIP or saline (3 times per week for 3 weeks) and [11C]PIB imaging was performed at baseline, after the treatment and after 3 months follow-up period, accompanied by Aβ immunohistochemistry and ELISA. After the treatment, [11C]PIB binding ratios between mApoE-PA-LIP and saline groups were equivalent in all analyzed brain regions; however, in the saline group, binding ratios increased from the baseline, whereas no increase was detected in the mApoE-PA-LIP group. During the additional follow-up, [11C]PIB binding increased significantly from baseline in both groups, and binding ratios correlated with the immunohistochemically defined Aβ load. This study further supports the use of [11C]PIB positron emission tomography imaging as a biomarker of Aβ deposition in APP23 mice and highlights the benefits of noninvasive follow-up, that is, using baseline data for animal stratification and normalization of treatment effects to baseline values, for future anti-amyloid treatment studies.

Journal

Neurobiology of Aging – Elsevier

Published: Sep 1, 2017

References

  • Multifunctional liposomes reduce brain β-amyloid burden and ameliorate memory impairment in Alzheimer's disease mouse models
    Balducci, C.; Mancini, S.; Minniti, S.; La Vitola, P.; Zotti, M.; Sancini, G.; Mauri, M.; Cagnotto, A.; Colombo, L.; Fiordaliso, F.; Grigoli, E.; Salmona, M.; Snellman, A.; Haaparanta-Solin, M.; Forloni, G.; Masserini, M.; Re, F.
  • Liposomes bi-functionalized with phosphatidic acid and an ApoE-derived peptide affect Aβ aggregation features and cross the blood-brain-barrier: implications for therapy of Alzheimer disease
    Bana, L.; Minniti, S.; Salvati, E.; Sesana, S.; Zambelli, V.; Cagnotto, A.; Orlando, A.; Cazzaniga, E.; Zwart, R.; Scheper, W.; Masserini, M.; Re, F.
  • Liposomes as nanomedical devices
    Bozzuto, G.; Molinari, A.
  • Impact of partial volume effect correction on cerebral β-amyloid imaging in APP-Swe mice using [(18)F]-florbetaben PET
    Brendel, M.; Delker, A.; Rötzer, C.; Böning, G.; Carlsen, J.; Cyran, C.; Mille, E.; Gildehaus, F.J.; Cumming, P.; Baumann, K.; Steiner, H.; Haass, C.; Herms, J.; Bartenstein, P.; Rominger, A.
  • Cross-sectional comparison of small animal [18F]-Florbetaben amyloid-PET between transgenic ad mouse models
    Brendel, M.; Jaworska, A.; Grießinger, E.; Rötzer, C.; Burgold, S.; Gildehaus, F.J.; Carlsen, J.; Cumming, P.; Baumann, K.; Haass, C.; Steiner, H.; Bartenstein, P.; Herms, J.; Rominger, A.
  • Monitoring of chronic γ-secretase modulator treatment by serial amyloid-PET
    Brendel, M.; Jaworska, A.; Herms, J.; Trambauer, J.; Rötzer, C.; Gildehaus, F.J.; Carlsen, J.; Cumming, P.; Bylund, J.; Luebbers, T.; Bartenstein, P.; Steiner, H.; Haass, C.; Baumann, K.; Rominger, A.
  • Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria
    Dubois, B.; Feldman, H.H.; Jacova, C.; Hampel, H.; Molinuevo, J.L.; Blennow, K.; DeKosky, S.T.; Gauthier, S.; Selkoe, D.; Bateman, R.; Cappa, S.; Crutch, S.; Engelborghs, S.; Frisoni, G.B.; Fox, N.C.; Galasko, D.; Habert, M.O.; Jicha, G.A.; Nordberg, A.; Pasquier, F.; Rabinovici, G.; Robert, P.; Rowe, C.; Salloway, S.; Sarazin, M.; Epelbaum, S.; de Souza, L.C.; Vellas, B.; Visser, P.J.; Schneider, L.; Stern, Y.; Scheltens, P.; Cummings, J.L.
  • Lipid-based nanoparticles with high binding affinity for amyloid-beta1-42 peptide
    Gobbi, M.; Re, F.; Canovi, M.; Beeg, M.; Gregori, M.; Sesana, S.; Sonnino, S.; Brogioli, D.; Musicanti, C.; Gasco, P.; Salmona, M.; Masserini, M.E.
  • Biological markers of amyloid beta-related mechanisms in Alzheimer's disease
    Hampel, H.; Shen, Y.; Walsh, D.M.; Aisen, P.; Shaw, L.M.; Zetterberg, H.; Trojanowski, J.Q.; Blennow, K.
  • The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics
    Hardy, J.; Selkoe, D.J.
  • Alzheimer's disease: the amyloid cascade hypothesis
    Hardy, J.A.; Higgins, G.A.
  • A simple synthesis of [11C]methyl triflate
    Jewett, D.M.
  • The amyloid cascade hypothesis: are we poised for success or failure?
    Karran, E.; De Strooper, B.
  • A critique of the drug discovery and phase 3 clinical programs targeting the amyloid hypothesis for Alzheimer disease
    Karran, E.; Hardy, J.
  • Binding of the positron emission tomography tracer Pittsburgh compound-B reflects the amount of amyloid-beta in Alzheimer's disease brain but not in transgenic mouse brain
    Klunk, W.E.; Lopresti, B.J.; Ikonomovic, M.D.; Lefterov, I.M.; Koldamova, R.P.; Abrahamson, E.E.; Debnath, M.L.; Holt, D.P.; Huang, G.F.; Shao, L.; DeKosky, S.T.; Price, J.C.; Mathis, C.A.
  • Synthesis of 11C-iodomethane by iodination of 11C-methaneSynthesis of 11C-iodomethane by iodination of 11C-methane
    Larsen, P.; Ulin, J.; Dahlstrom, K.; Jensen, M.
  • Longitudinal, quantitative assessment of amyloid, neuroinflammation, and anti-amyloid treatment in a living mouse model of Alzheimer's disease enabled by positron emission tomography
    Maeda, J.; Ji, B.; Irie, T.; Tomiyama, T.; Maruyama, M.; Okauchi, T.; Staufenbiel, M.; Iwata, N.; Ono, M.; Saido, T.C.; Suzuki, K.; Mori, H.; Higuchi, M.; Suhara, T.
  • Longitudinal PET-MRI reveals β-amyloid deposition and rCBF dynamics and connects vascular amyloidosis to quantitative loss of perfusion
    Maier, F.C.; Wehrl, H.F.; Schmid, A.M.; Mannheim, J.G.; Wiehr, S.; Lerdkrai, C.; Calaminus, C.; Stahlschmidt, A.; Ye, L.; Burnet, M.; Stiller, D.; Sabri, O.; Reischl, G.; Staufenbiel, M.; Garaschuk, O.; Jucker, M.; Pichler, B.J.
  • The hunt for brain Abeta oligomers by peripherally circulating multi-functional nanoparticles: potential therapeutic approach for Alzheimer disease
    Mancini, S.; Minniti, S.; Gregori, M.; Sancini, G.; Cagnotto, A.; Couraud, P.O.; Ordonez-Gutierrez, L.; Wandosell, F.; Salmona, M.; Re, F.
  • Small-animal PET imaging of amyloid-beta plaques with [C]PiB and its multi-Modal validation in an APP/PS1 mouse model of Alzheimer's disease
    Manook, A.; Yousefi, B.H.; Willuweit, A.; Platzer, S.; Reder, S.; Voss, A.; Huisman, M.; Settles, M.; Neff, F.; Velden, J.; Schoor, M.; von der Kammer, H.; Wester, H.J.; Schwaiger, M.; Henriksen, G.; Drzezga, A.
  • Mouse MRI Brain Template. MRM NAt Mouse Brain Database
    Mouse MRI brain template
  • Functionalization with ApoE-derived peptides enhances the interaction with brain capillary endothelial cells of nanoliposomes binding amyloid-beta peptide
    Re, F.; Cambianica, I.; Sesana, S.; Salvati, E.; Cagnotto, A.; Salmona, M.; Couraud, P.O.; Moghimi, S.M.; Masserini, M.; Sancini, G.
  • Functionalization of liposomes with ApoE-derived peptides at different density affects cellular uptake and drug transport across a blood-brain barrier model
    Re, F.; Cambianica, I.; Zona, C.; Sesana, S.; Gregori, M.; Rigolio, R.; La Ferla, B.; Nicotra, F.; Forloni, G.; Cagnotto, A.; Salmona, M.; Masserini, M.; Sancini, G.
  • Nanotechnology for neurodegenerative disorders
    Re, F.; Gregori, M.; Masserini, M.
  • Longitudinal assessment of cerebral β-amyloid deposition in mice overexpressing Swedish mutant β-amyloid precursor protein using 18F-florbetaben PET
    Rominger, A.; Brendel, M.; Burgold, S.; Keppler, K.; Baumann, K.; Xiong, G.; Mille, E.; Gildehaus, F.J.; Carlsen, J.; Schlichtiger, J.; Niedermoser, S.; Wängler, B.; Cumming, P.; Steiner, H.; Herms, J.; Haass, C.; Bartenstein, P.
  • Amyloid load and translocator protein 18 kDa in APPswePS1-dE9 mice: a longitudinal study
    Sérrière, S.; Tauber, C.; Vercouillie, J.; Mothes, C.; Pruckner, C.; Guilloteau, D.; Kassiou, M.; Doméné, A.; Garreau, L.; Page, G.; Chalon, S.
  • Longitudinal amyloid imaging in mouse brain with 11C-PIB: comparison of APP23, Tg2576, and APPswe-PS1dE9 mouse models of Alzheimer disease
    Snellman, A.; López-Picón, F.R.; Rokka, J.; Salmona, M.; Forloni, G.; Scheinin, M.; Solin, O.; Rinne, J.O.; Haaparanta-Solin, M.
  • In vivo PET imaging of beta-amyloid deposition in mouse models od Alzheimer's disease with a high specific activity PET imaging agent [18F]flutemetamol
    Snellman, A.; Rokka, J.; López Picón, F.R.; Eskola, O.; Salmona, M.; Forloni, G.; Scheinin, M.; Solin, O.; Rinne, J.O.; Haaparanta-Solin, M.
  • Pharmacokinetics of [(18)F]flutemetamol in wild-type rodents and its binding to beta amyloid deposits in a mouse model of Alzheimer's disease
    Snellman, A.; Rokka, J.; Lopez-Picon, F.R.; Eskola, O.; Wilson, I.; Farrar, G.; Scheinin, M.; Solin, O.; Rinne, J.O.; Haaparanta-Solin, M.
  • Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology
    Sturchler-Pierrat, C.; Abramowski, D.; Duke, M.; Wiederhold, K.H.; Mistl, C.; Rothacher, S.; Ledermann, B.; Bürki, K.; Frey, P.; Paganetti, P.A.; Waridel, C.; Calhoun, M.E.; Jucker, M.; Probst, A.; Staufenbiel, M.; Sommer, B.
  • Pathogenic mechanisms of Alzheimer's disease analyzed in the APP23 transgenic mouse model
    Sturchler-Pierrat, C.; Staufenbiel, M.
  • Health economic evaluation of treatments for Alzheimer's disease: impact of new diagnostic criteria
    Wimo, A.; Ballard, C.; Brayne, C.; Gauthier, S.; Handels, R.; Jones, R.W.; Jonsson, L.; Khachaturian, A.S.; Kramberger, M.
  • MicroPET imaging and transgenic models: a blueprint for Alzheimer's disease clinical research
    Zimmer, E.R.; Parent, M.J.; Cuello, A.C.; Gauthier, S.; Rosa-Neto, P.

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