Apolipoprotein E4: Another risk factor for cholesterol gallstone formation?

Apolipoprotein E4: Another risk factor for cholesterol gallstone formation? 1764 EDITORIALS GASTROENTEROLOGY Vol. 111, No. 6 See article on page 1603. Apolipoprotein E4 gives you a double dose of nuts: it makes you mad and also ``stoned'' . . . --Letter of E. Ros to M.C. Carey April 16, 1966 polipoprotein (apo) E is a ligand for the low-density lipoprotein (LDL) family of receptors and plays a pivotal role in cholesterol metabolism. Although synthesized principally in the liver, apo E can be produced by many extrahepatic cells including macrophages and glial cells of the central nervous system. Three common isoforms (E2, E3, and E4) accounting for 99% of the variation within the population have been identified. The differences between the isoforms result from interchanges of cysteine and arginine at positions 112 and 158 of the molecule, which contains a total of 299 amino acids. In apo E2, cysteine occurs at both positions; in apo E4, arginine is located at both positions; and in apo E3, cysteine occupies position 112 and arginine position 158. A single gene, located on human chromosome 19 in a cluster with apolipoprotein CI and CII genes, encodes the isoforms. Because the isoforms are expressed codominantly, six possible phenotypes are generated: E2/2, E3/ 3, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Gastroenterology Elsevier

Apolipoprotein E4: Another risk factor for cholesterol gallstone formation?

Gastroenterology, Volume 111 (6) – Dec 1, 1996

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Publisher
Elsevier
Copyright
Copyright © 1996 American Gastroenterological Association
ISSN
0016-5085
eISSN
1528-0012
DOI
10.1016/S0016-5085(96)70044-6
Publisher site
See Article on Publisher Site

Abstract

1764 EDITORIALS GASTROENTEROLOGY Vol. 111, No. 6 See article on page 1603. Apolipoprotein E4 gives you a double dose of nuts: it makes you mad and also ``stoned'' . . . --Letter of E. Ros to M.C. Carey April 16, 1966 polipoprotein (apo) E is a ligand for the low-density lipoprotein (LDL) family of receptors and plays a pivotal role in cholesterol metabolism. Although synthesized principally in the liver, apo E can be produced by many extrahepatic cells including macrophages and glial cells of the central nervous system. Three common isoforms (E2, E3, and E4) accounting for 99% of the variation within the population have been identified. The differences between the isoforms result from interchanges of cysteine and arginine at positions 112 and 158 of the molecule, which contains a total of 299 amino acids. In apo E2, cysteine occurs at both positions; in apo E4, arginine is located at both positions; and in apo E3, cysteine occupies position 112 and arginine position 158. A single gene, located on human chromosome 19 in a cluster with apolipoprotein CI and CII genes, encodes the isoforms. Because the isoforms are expressed codominantly, six possible phenotypes are generated: E2/2, E3/ 3,

Journal

GastroenterologyElsevier

Published: Dec 1, 1996

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