Anxiolytic-like effect of neuropeptide Y (NPY) and NPY 13–36 microinjected into vicinity of locus coeruleus in rats

Anxiolytic-like effect of neuropeptide Y (NPY) and NPY 13–36 microinjected into vicinity of... Neuropeptide Y (NPY, 1 and 10 pmol), NPY Y 1 receptor agonist (Leu 31 ,Pro 34 )NPY (10 pmol) and Y 2 agonist NPY 13–36 (100 pmol) were administered unilaterally into the region of the nucleus locus coeruleus (LC) in rats. NPY (10 pmol) and NPY 13–36 increased the percentage of open arm entries, the percentage of time spent on open part, number of both open and closed arm entries and line crossings in the open part while (Leu 31 ,Pro 34 )NPY failed to modify elevated plus-maze behavior. These data suggest that NPY applied close to LC has anxiolytic-like effects by acting on NPY Y 2 , not on Y 1 receptors. Thus, NPY Y 2 receptors in the vicinity of LC may be involved in the regulation of anxiety in rats. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Brain Research Elsevier

Anxiolytic-like effect of neuropeptide Y (NPY) and NPY 13–36 microinjected into vicinity of locus coeruleus in rats

Brain Research, Volume 788 (1) – Mar 30, 1998

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Publisher
Elsevier
Copyright
Copyright © 1998 Elsevier Science B.V.
ISSN
0006-8993
DOI
10.1016/S0006-8993(98)00076-6
Publisher site
See Article on Publisher Site

Abstract

Neuropeptide Y (NPY, 1 and 10 pmol), NPY Y 1 receptor agonist (Leu 31 ,Pro 34 )NPY (10 pmol) and Y 2 agonist NPY 13–36 (100 pmol) were administered unilaterally into the region of the nucleus locus coeruleus (LC) in rats. NPY (10 pmol) and NPY 13–36 increased the percentage of open arm entries, the percentage of time spent on open part, number of both open and closed arm entries and line crossings in the open part while (Leu 31 ,Pro 34 )NPY failed to modify elevated plus-maze behavior. These data suggest that NPY applied close to LC has anxiolytic-like effects by acting on NPY Y 2 , not on Y 1 receptors. Thus, NPY Y 2 receptors in the vicinity of LC may be involved in the regulation of anxiety in rats.

Journal

Brain ResearchElsevier

Published: Mar 30, 1998

References

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