Anxiogenic effect of central CCK administration is attenuated by chronic fluoxetine or ipsapirone treatment 1 Parts of this data was presented at the 4th IUPHAR Satellite Meeting on Serotonin, Rotterdam, July 23–25, 1998. 1

Anxiogenic effect of central CCK administration is attenuated by chronic fluoxetine or ipsapirone... The effect of chronic fluoxetine and ipsapirone treatment on the anxiogenic effect of centrally administered cholecystokinin (CCK) was studied in the social interaction test in male Sprague–Dawley rats. Intracerebroventricular injection of unsulfated CCK-8 significantly decreased total interaction time and locomotor activity and caused some increase in selfgrooming and a reduction in rearing behaviour in a familiar arena in low light conditions. The selective serotonin reuptake inhibitor antidepressant fluoxetine alone (5 mg/kg, i.p.) also had clear acute anxiogenic actions (decrease in total interaction time, locomotor activity, rearing, increase in selfgrooming) after single dosing, but all these effects were omitted after chronic (3 weeks) treatment. In contrast, a single injection of the 5-HT 1A receptor partial agonist ipsapirone (5 mg/kg, i.p.) alone had only motor effects (decrease in selfgrooming and rearing), and these effects were preserved after chronic treatment. Chronic fluoxetine treatment (5 mg/kg per day, 3 weeks) abolished the effects of CCK-8 (1 nmol/rat, i.c.v.). Chronic treatment with ipsapirone (5 mg/kg per day, 3 weeks) partially attenuated the effects of CCK-8 (1 nmol/rat, i.c.v.). Our studies provide further evidence for a 5-HT/CCK interaction in the regulation of anxiety. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Neuropharmacology Elsevier

Anxiogenic effect of central CCK administration is attenuated by chronic fluoxetine or ipsapirone treatment 1 Parts of this data was presented at the 4th IUPHAR Satellite Meeting on Serotonin, Rotterdam, July 23–25, 1998. 1

Neuropharmacology, Volume 38 (2) – Feb 1, 1999

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Publisher
Elsevier
Copyright
Copyright © 1999 Elsevier Science Ltd
ISSN
0028-3908
eISSN
1873-7064
DOI
10.1016/S0028-3908(98)00176-2
Publisher site
See Article on Publisher Site

Abstract

The effect of chronic fluoxetine and ipsapirone treatment on the anxiogenic effect of centrally administered cholecystokinin (CCK) was studied in the social interaction test in male Sprague–Dawley rats. Intracerebroventricular injection of unsulfated CCK-8 significantly decreased total interaction time and locomotor activity and caused some increase in selfgrooming and a reduction in rearing behaviour in a familiar arena in low light conditions. The selective serotonin reuptake inhibitor antidepressant fluoxetine alone (5 mg/kg, i.p.) also had clear acute anxiogenic actions (decrease in total interaction time, locomotor activity, rearing, increase in selfgrooming) after single dosing, but all these effects were omitted after chronic (3 weeks) treatment. In contrast, a single injection of the 5-HT 1A receptor partial agonist ipsapirone (5 mg/kg, i.p.) alone had only motor effects (decrease in selfgrooming and rearing), and these effects were preserved after chronic treatment. Chronic fluoxetine treatment (5 mg/kg per day, 3 weeks) abolished the effects of CCK-8 (1 nmol/rat, i.c.v.). Chronic treatment with ipsapirone (5 mg/kg per day, 3 weeks) partially attenuated the effects of CCK-8 (1 nmol/rat, i.c.v.). Our studies provide further evidence for a 5-HT/CCK interaction in the regulation of anxiety.

Journal

NeuropharmacologyElsevier

Published: Feb 1, 1999

References

  • Can social interaction be used to measure anxiety?
    File, S.E.; Hyde, J.R.G.
  • 5-HT 1A and benzodiazepine receptors in the basolateral amygdala modulate anxiety in the social interaction test, but not in the elevated plus-maze
    Gonzalez, L.E.; Andrews, N.; File, S.E.
  • Cholecystokinin activates area postrema neurons in rat brain slices
    Sun, K.; Ferguson, A.V.
  • Effect of the selective serotonin reuptake inhibitor fluvoxamine on CCK-4 induced panic attacks
    van Megen, H.J.G.M.; Westenberg, H.G.M.; den Boer, J.A.; Slaap, B.; Scheepmakers, A.

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