Antioxidative activity of ginkgolides against superoxide in an aprotic environment

Antioxidative activity of ginkgolides against superoxide in an aprotic environment The terpene lactones ginkgolide A, ginkgolide B, ginkgolide C, ginkgolide J and bilobalide, which are components of a standardized extract (EGb 761) from leaves of Ginkgo biloba , as well as ginkgolide M from roots of G. biloba were studied regarding their reaction against superoxide (O 2 − ) and hydroperoxyl radicals (HO 2 ) in dimethyl sulfoxide as an aprotic solvent. It was found that the ginkgolides B, C, J, M as well as bilobalide react with superoxide and its protonated form as demonstrated by EPR and UV/VIS spectroscopy. The initial reaction rate with these oxygen-derived radicals is in the order of 100 M −1 /s and below. Ginkgolide A does not react with superoxide under these conditions. From these findings it can be suggested that the superoxide scavenging effect of the ginkgolides B, C, J, M and bilobalide contributes to the antioxidant properties of G. biloba . http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Chemico-Biological Interactions Elsevier

Antioxidative activity of ginkgolides against superoxide in an aprotic environment

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Publisher
Elsevier
Copyright
Copyright © 1997 Elsevier Ltd
ISSN
0009-2797
D.O.I.
10.1016/S0009-2797(97)00067-7
Publisher site
See Article on Publisher Site

Abstract

The terpene lactones ginkgolide A, ginkgolide B, ginkgolide C, ginkgolide J and bilobalide, which are components of a standardized extract (EGb 761) from leaves of Ginkgo biloba , as well as ginkgolide M from roots of G. biloba were studied regarding their reaction against superoxide (O 2 − ) and hydroperoxyl radicals (HO 2 ) in dimethyl sulfoxide as an aprotic solvent. It was found that the ginkgolides B, C, J, M as well as bilobalide react with superoxide and its protonated form as demonstrated by EPR and UV/VIS spectroscopy. The initial reaction rate with these oxygen-derived radicals is in the order of 100 M −1 /s and below. Ginkgolide A does not react with superoxide under these conditions. From these findings it can be suggested that the superoxide scavenging effect of the ginkgolides B, C, J, M and bilobalide contributes to the antioxidant properties of G. biloba .

Journal

Chemico-Biological InteractionsElsevier

Published: Oct 24, 1997

References

  • Ginkgo biloba extract protects human low density lipoproteins against oxidative modification mediated by copper
    Yan, L.J.; Drog-Lefaix, M.T.; Packer, L.
  • Protective effect of the PAF antagonist BN 52021 in an experimental renal warm ischemia model
    Torras, J.; Bordalba, J.R.; Seron, D.; Moliner, R.; Carrera, M.; Valles, J.; Martinez-Castelao, A.; Alsina, J.; Grino, J.M.
  • Platelet-activating factor antagonist BN52021 decreases accumulation of free polyunsaturated fatty acid in mouse brain during ischemia and electroconvulsive shock
    Birkle, D.L.; Kurian, P.; Braquet, P.; Bazan, N.G.

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