Antioxidant and antiproliferative activities of common edible nut seeds

Antioxidant and antiproliferative activities of common edible nut seeds Frequent consumption of nuts has been linked to a lowered risk of cardiovascular disease. Phytochemicals, especially phenolics, in nuts may be considered to be the major bioactive compounds for health benefits. Nine types of tree nuts and peanuts commonly available in the United States were evaluated for total phenolic and flavonoid contents, antioxidant, and antiproliferative activities. The profiles of total phenolics and flavonoids, including both soluble free and bound forms, were investigated by utilizing solvent extraction, base digestion, and solid-phase extraction methods. Walnuts had the highest total phenolic and flavonoid contents (1580.5 ± 58.0 mg/100 g, 744.8 ± 93.3 mg/100 g, respectively). Walnuts also possessed the highest total antioxidant activity (458.1 ± 14.0 μmol of vitamin C equiv/g of nut). Both soluble phenolic and flavonoid contents were positively correlated with total antioxidant activity ( R 2 = 0.9901, p < 0.05; and R 2 = 0.9749, p < 0.05, respectively). The proliferation of HepG 2 and Caco-2 cells was significantly inhibited in a dose-dependent pattern after exposure to the extracts of nuts, with walnuts and pecans exhibiting the highest antiproliferative activity. These results provide new knowledge about health functions of nuts and may influence consumers toward purchasing nuts exhibiting greater potential health benefits. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png LWT - Food Science and Technology Elsevier

Antioxidant and antiproliferative activities of common edible nut seeds

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Publisher
Elsevier
Copyright
Copyright © 2008 Swiss Society of Food Science and Technology
ISSN
0023-6438
D.O.I.
10.1016/j.lwt.2008.07.007
Publisher site
See Article on Publisher Site

Abstract

Frequent consumption of nuts has been linked to a lowered risk of cardiovascular disease. Phytochemicals, especially phenolics, in nuts may be considered to be the major bioactive compounds for health benefits. Nine types of tree nuts and peanuts commonly available in the United States were evaluated for total phenolic and flavonoid contents, antioxidant, and antiproliferative activities. The profiles of total phenolics and flavonoids, including both soluble free and bound forms, were investigated by utilizing solvent extraction, base digestion, and solid-phase extraction methods. Walnuts had the highest total phenolic and flavonoid contents (1580.5 ± 58.0 mg/100 g, 744.8 ± 93.3 mg/100 g, respectively). Walnuts also possessed the highest total antioxidant activity (458.1 ± 14.0 μmol of vitamin C equiv/g of nut). Both soluble phenolic and flavonoid contents were positively correlated with total antioxidant activity ( R 2 = 0.9901, p < 0.05; and R 2 = 0.9749, p < 0.05, respectively). The proliferation of HepG 2 and Caco-2 cells was significantly inhibited in a dose-dependent pattern after exposure to the extracts of nuts, with walnuts and pecans exhibiting the highest antiproliferative activity. These results provide new knowledge about health functions of nuts and may influence consumers toward purchasing nuts exhibiting greater potential health benefits.

Journal

LWT - Food Science and TechnologyElsevier

Published: Jan 1, 2009

References

  • Phytochemicals and antioxidant activity of wheat varieties
    Adom, K.K.; Sorrells, M.E.; Liu, R.H.
  • Flavonoids; chemistry, metabolism, cardioprotective effects and dietary sources
    Cook, N.C.; Samman, S.
  • Whole almonds and almond fractions reduce aberrant crypt foci in a rat model of colon carcinogenesis
    Davis, P.A.; Iwahashi, C.K.
  • The determination of flavonoid contents in mulberry and their scavenging effects on superoxide radicals
    Jia, Z.; Tang, M.; Wu, J.
  • Bioactive compounds in foods: their role in the prevention of cardiovascular disease and cancer
    Kris-Etherton, P.M.; Hecker, K.D.; Bonanome, A.

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