Antimutagenic activity of tea towards 2-hydroxyamino-3-methylimidazo(4,5- f )quinoline: effect of tea concentration and brew time on electrophile scavenging

Antimutagenic activity of tea towards 2-hydroxyamino-3-methylimidazo(4,5- f )quinoline: effect of... Green tea and black tea inhibit colon carcinogenesis in rats exposed to the cooked meat-derived mutagen 2-amino-3-methylimidazo(4,5- f )quinoline (IQ). The present study compared the inhibitory activities of green tea and black tea towards a direct-acting mutagenic metabolite of IQ, namely 2-hydroxyamino-3-methylimidazo(4,5- f )quinoline ( N -hydroxy-IQ), under various brewing conditions. The following observations were made: (a) green tea (Sencha midoriiro) and black tea and (d) fractionation of green tea by HPLC revealed that most of the antimutagenic activity co-eluted with the compounds epigallocatechin (EGC) and epigallocatechin-3-gallate (EGCG), both of which are known for their anti-oxidant properties. These results suggest that catechins in tea might protect against such diverse reactive intermediates as free radicals and electrophiles formed during the metabolic activation of carcinogens and mutagens. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis Elsevier

Antimutagenic activity of tea towards 2-hydroxyamino-3-methylimidazo(4,5- f )quinoline: effect of tea concentration and brew time on electrophile scavenging

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Publisher
Elsevier
Copyright
Copyright © 1998 Elsevier Ltd
ISSN
0027-5107
D.O.I.
10.1016/S0027-5107(97)00309-6
Publisher site
See Article on Publisher Site

Abstract

Green tea and black tea inhibit colon carcinogenesis in rats exposed to the cooked meat-derived mutagen 2-amino-3-methylimidazo(4,5- f )quinoline (IQ). The present study compared the inhibitory activities of green tea and black tea towards a direct-acting mutagenic metabolite of IQ, namely 2-hydroxyamino-3-methylimidazo(4,5- f )quinoline ( N -hydroxy-IQ), under various brewing conditions. The following observations were made: (a) green tea (Sencha midoriiro) and black tea and (d) fractionation of green tea by HPLC revealed that most of the antimutagenic activity co-eluted with the compounds epigallocatechin (EGC) and epigallocatechin-3-gallate (EGCG), both of which are known for their anti-oxidant properties. These results suggest that catechins in tea might protect against such diverse reactive intermediates as free radicals and electrophiles formed during the metabolic activation of carcinogens and mutagens.

Journal

Mutation Research/Fundamental and Molecular Mechanisms of MutagenesisElsevier

Published: Jun 18, 1998

References

  • Protection by green tea, black tea, and indole-3-carbinol against 2-amino-3-methylimidazo(4,5- f )quinoline-induced DNA adducts and colonic aberrant crypts in the F344 rat
    Xu, M.; Bailey, A.C.; Hernaez, J.F.; Taoka, C.R.; Schut, H.A.J.; Dashwood, R.H.
  • Effects of tea and chlorophyllin on the mutagenicity of N -hydroxy-IQ: studies of enzyme inhibition, molecular complex formation and degradation/scavenging of the active metabolites
    Hernaez, J.; Xu, M.; Dashwood, R.H.

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